^(18)F-FDG PET/CT在乳腺癌术后复发及转移患者的应用价值  

Application value of ^(18)F-FDG PET/CT in evaluating recurrence and metastasis of patients with breast cancer after surgery

作　　者：赵飞 胡瑶 丁重阳 李天女 

机构地区：[1]南京医科大学第一附属医院PET/CT室,江苏省210029

出　　处：《江苏医药》2016年第7期771-774,共4页Jiangsu Medical Journal

基　　金：南京市科技计划项目(201303038);江苏省"六大人才高峰"基金(2013-WSN-039)

摘　　要：目的探讨^(18)氟-氟代脱氧葡萄糖(^(18)F-FDG)PET/CT在乳腺癌术后复发、转移患者的应用价值。方法回顾性分析乳腺癌术后临床怀疑复发或转移的49例患者的^(18)F-FDG PET/CT影像资料,并与同期传统影像学检查资料、血清肿瘤标记物和病理及临床随访结果进行对比。结果^(18)F-FDG PET/CT诊断乳腺癌术后复发及转移的灵敏度、特异度、准确性、阳性预测值和阴性预测值分别为81.6%、90.9%、83.7%、96.9%和58.8%。在血清肿瘤标记物升高的30例患者中,18 F-FDG PET/CT诊断乳腺癌术后复发及转移的灵敏度、特异度、准确性、阳性预测值和阴性预测值分别为84.6%、100%、86.7%、100%和50.0%。依据^(18)F-FDG PET/CT结果,73.5%患者更改了治疗方案。结论 ^(18)F-FDG PET/CT能有效评估乳腺癌术后复发及转移病例,指导临床治疗。Objective To estimate the clinical application value of （18）F-FDG PET/CT in evaluating the recurrence and metastasis of the patients with breast cancer after surgery.Methods The imaging data of （18）F-FDG PET/CT in 49 patients with breast cancer after surgery who were suspected to have recurrence and metastasis were retrospectively analyzed.The results were compared with those of conventional imaging data,serum tumor markers and pathological and clinical follow-up.Results The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of（18）F-FDG PET/CT for detecting the recurrence and metastasis in the patients with breast cancer after surgery were 81.6%,90.9%,83.7%,96.9% and 58.8%,respectively.In 30 cases with elevated serum tumor markers,the sensitivity,specificity,accuracy,positive predictive value and negative predictive value of （18）F-FDG PET/CT for detecting the recurrence and metastasis were 84.6%,100%,86.7%,100% and 50.0%,respectively.On the basis of imaging data of （18）F-FDG PET/CT,the treatment plans were changed in 73.5% of the patients.Conclusion （18）F-FDG PET/CT is able to detect recurrence and metastasis after breast cancer surgery,evaluate the patients condition and guide the clinical treatment plan.

关 键 词：乳腺癌 正电子发射断层显像/X射线计算机体层成像 18氟-氟代脱氧葡萄糖 

分 类 号：R445[医药卫生—影像医学与核医学]