右美托咪定对七氟烷麻醉后认知功能及相关细胞因子含量的影响  

Effect of dexmedetomidine on cognitive function and related cytokine contents after sevoflurane anesthesia

作　　者：韩庆波[1] 

机构地区：[1]河北省唐山市开滦总医院麻醉科

出　　处：《海南医学院学报》2016年第11期1156-1159,共4页Journal of Hainan Medical University

基　　金：国家科技支撑计划项目(2008BAI52B03)~~

摘　　要：目的：分析右美托咪定对七氟烷麻醉后认知功能及相关细胞因子含量的影响。方法：118例在本院接受手术治疗的患者,均接受七氟烷静吸复合麻醉,根据术中右美托咪定的应用与否将所有入组患者分为观察组及对照组各59例。对照组接受单纯七氟醚静吸复合麻醉,观察组在静吸复合麻醉基础上加入右美托咪定,对比两组血流动力学参数、免疫功能指标、认知相关指标、病情相关指标值等差异。结果：T2及T3时观察组CVP值高于对照组,Rv、CO、CI值低于对照组（P〈0.05）;T2及T3时观察组的CD3^＋、CD4^＋、CD8^＋、CD16^＋/CD56^＋值均高于对照组,TNF-α、IL-1β值低于对照组（P〈0.05）;观察组术后即刻血清BDNF、S100β、β-EP值低于对照组,ChAT、NGF值高于对照组（P〈0.05）;观察组的术后即刻血清HIF-1α值高于对照组,ALD、NF-κB、sICAM-1值低于对照组（P〈0.05）。结论：七氟烷麻醉中应用右美托咪定可以保护患者的认知功能并稳定循环,有助于术后机体功能的恢复。Objective：To analyze the effects of dexmedetomidine on cognitive function and related cytokine contents after sevoflurane anesthesia.Methods：A total of 118 patients who underwent surgical treatment in our hospital and received sevoflurane intravenous-inhalation combined anesthesia were enrolled and divided into observation group and control group according to use of intraoperative dexmedetomidine or not with 59 cases in each group.Control group received sevoflurane intravenous-inhalation combined anesthesia alone,observation group received dexmedetomidine on the basis of intravenous-inhalation combined anesthesia,and then differences in the values of hemodynamic parameters,immune function indicators,cognition-related indicators,illness-related indicators were compared between two groups.Results：CVP values of observation group at T2 and T3 were higher than those of control group,and Rv,CO and CI values were lower than those of control group（P〈0.05）;CD3^＋,CD4^＋,CD8^＋and CD16^＋/CD56^＋values of observation group at T2 and T3 were higher than those of control group,and TNF-αand IL-1β values were lower than those of control group（P〈0.05）;serum BDNF,S100βandβ-EP values of observation group immediately after operation were lower than those of control group,and ChAT and NGF values were higher than those of control group（P〈0.05）;serum HIF-1α value of observation group immediately after operation was higher than that of control group,and ALD,NF-κB and sICAM-1 values were lower than those of control group（P〈0.05）.Conclusion：Application of dexmedetomidine in sevoflurane anesthesia can protect patients＇ cognitive function and stabilize circulation,it helps to postoperative body function recovery.

关 键 词：麻醉 七氟烷 右美托咪定 认知功能 

分 类 号：R614[医药卫生—麻醉学]