对比分析短效与长效硝苯地平治疗妊娠高血压的临床疗效  

Comparative analysis of clinical efficacy of short acting and long-acting nifedipine treatment of hypertension in pregnancy

作　　者：任晓萍 

机构地区：[1]四川省德阳市第六人民医院妇产科,四川德阳618000

出　　处：《吉林医学》2016年第4期811-813,共3页Jilin Medical Journal

摘　　要：目的:对比分析短效与长效硝苯地平治疗妊娠高血压的临床疗效。方法:对照组应用硫酸镁及短效硝苯地平进行治疗,研究组应用硫酸镁及长效硝苯地平进行治疗。对比两组患者治疗前后收缩压及舒张压的变化,对比两组分娩方式及胎儿不良事件情况,对比两组孕妇产程并发症发生情况。结果:两组治疗前收缩压及舒张压无显著差异(P>0.05),治疗后两组收缩压及舒张压均显著下降(P<0.05),研究组其血压下降幅度显著优于对照组(P<0.05)。研究组自然分娩率显著显著优于对照组(P<0.05),研究组胎儿窘迫发生率显著低于对照组(P<0.05),两组胎儿死亡率无显著差异(P>0.05)。研究组胎盘早剥、胎膜早破及产后出血发生率显著低于对照组(P<0.05)。结论:妊娠高血压应用长效硝苯地平可显著降低血压,促进自然分娩,降低胎儿不良事件及产程不良事件。Objective To compare the clinical efficacy of short acting and long- acting nifedipine treatment of hypertension in pregnancy. Method The control group were treated with sulfuric acid magnesium and short acting nifedipine treatment,the study group were treated with magnesium sulfate and long- acting nifedipine treatment. The changes of systolic blood pressure and diastolic blood pressure were compared between two groups before and after treatment,compared with the two groups of delivery mode and fetal adverse events,and compared the occurrence of complications in the two groups. Results Systolic blood pressure and diastolic blood pressure had no significant difference with two groups before treatment（ P〈0. 05）,after treatment,systolic blood pressure and diastolic blood pressure were significantly decreased（ P〈0. 05）,the blood pressure of the study group decreased significantly,which was better than the control group（ P〈0. 05）. The natural birth rate of the study group was significantly better than the control group（ P〈0. 05）,the rate of fetal distress of the study group was significantly lower than that of the control group（ P〈0. 05）. Two groups of fetal mortality without significant difference（ P〈0. 05）. The incidence of placental premature rupture of membranes,premature rupture of membranes and postpartum hemorrhage were significantly lower in the study group than in the control group（ P〈0. 05）. Conclusion Pregnancy induced hypertension by nifedipine can significantly reduced blood pressure,promote natural delivery,reduce fetal adverse events and the production process of adverse events.

关 键 词：妊娠高血压 硝苯地平 钙离子拮抗剂 

分 类 号：R714.246[医药卫生—妇产科学]