不同浓度癸酸钠对总丹酚酸大鼠肠吸收的影响  

Effect of Different Concentrations of Sodium Caprate on Intestinal Absorption of Salvianolic Acids in Rats

作　　者：梁红萍[1] 邢丹丹[1] 梁诗婷 石心红[1] 邢为藩 

机构地区：[1]中国药科大学中药学院,南京211198 [2]南京艾利珂药业有限公司,南京211122

出　　处：《中国药学杂志》2016年第8期650-654,共5页Chinese Pharmaceutical Journal

摘　　要：目的研究总丹酚酸及配伍不同浓度癸酸钠后于大鼠不同肠段的肠吸收情况。方法采用在体大鼠单向肠灌流法,利用HPLC测定灌流液紫草酸,迷迭香酸和丹酚酸B浓度,计算相关的肠吸收参数Ka和Papp。结果 800μg·m L-1总丹酚酸浓度下,紫草酸各肠段的吸收:十二指肠≈空肠﹥回肠;迷迭香酸各肠段的吸收:回肠﹥空肠﹥十二指肠;丹酚酸B各肠段的吸收:回肠﹥空肠≈十二指肠。总丹酚酸配伍不同浓度癸酸钠后,低浓度癸酸钠轻微抑制了紫草酸和丹酚酸B吸收,而中、高浓度癸酸钠均能够较好的促进各组分肠吸收。结论癸酸钠具促进丹酚酸肠吸收作用,且随着浓度增大,促吸收作用显著增加。OBJECTIVE Investigate different intestinal segments absorption of salvianolic acids and compatibility of different concentration of sodium caprate in rats. METHODS Using single-pass intestinal perfusion model,three concentrations of lithospermic acid,rosmarinic acid and salvianolic acid B was determined by HPLC,and the intestinal absorption parameters of Kaand Pappwas calculated. RESULTS When salvianolic acids concentrion was 800 μg ·mL^- 1salvianolic acids concentration,absorption of lithospermic acid of various intestinal segments： duodenum≈jejunum ﹥ ileum; absorption of rosmarinic acid： ileum ﹥ jejunum ﹥ duodenum; absorption of salvianolic acid B： ileum ﹥ jejunum≈duodenum. After salvianolic acids combined with different concentrations of sodium caprate,low concentration of sodium caprate slightly inhibited the lithospermic acid and salvianolic acid B uptake,middle and high concentration sodium caprate were able to better promote salvianolic acids intestinal absorption. CONCLUSION Sodium caprate can promote intestinal absorption of salvianolic acids. With sodium caprate concentration increasing,absorption enhancing effect is more significant.

关 键 词：丹酚酸 癸酸钠 单向肠灌流 肠吸收 促吸收作用 

分 类 号：R969[医药卫生—药理学]