病毒性心肌炎患儿治疗前后外周血T细胞亚群变化分析  

Analysis of changes of T lymphocyte subsets in child viral myocarditis before and after treatment

作　　者：宋建[1] 崔北勇[1] 王绪韶[1] 杨忠诚[1] 胡华靖 

机构地区：[1]安徽省蚌埠市第一人民医院儿科,233000

出　　处：《淮海医药》2016年第3期274-275,278,共3页Journal of Huaihai Medicine

摘　　要：目的:观察病毒性心肌炎患儿外周血T细胞亚群变化,探讨其发病机制及其与预后关系。方法:采用流式细胞技术检测2014年2月-2015年2月在蚌埠市第一人民医院初诊及治疗的40例病毒性心肌炎患儿(患儿组)外周血T细胞亚群水平;对照组为40例同期健康体检儿童。结果:患儿组患儿入院时外周血CD3,CD4,CD4/CD8比值低于对照组,CD8高于对照组,差异有统计学意义(P<0.05);患儿组患儿入院时与治疗有效后T细胞亚群较对照组,CD3,CD4升高,CD8下降,CD4/CD8比值基本正常,差异有统计学意义(P<0.05)。结论:病毒性心肌炎患儿机体存在细胞免疫失调,外周血T细胞亚群水平变化对病毒性心肌炎的发生、发展及预后判断有重要作用。Objective： To study the changes of T lymphocyte subsets and to explore the possible pathogenesis and its relationship with prognosis. Methods： T lymphocyte subsets in the peripheral blood were determined with flow cytometry. 40 patients with viral myocarditis（ VMC） and 40 healthy children were selected in this study. The difference in age and sex between the two groups was not significant. Results： In the VMC group on admission,CD3,CD4 and the ratio of CD4 / CD8 of T lymphocyte subsets were significantly lower than those of the control group. CD8 of T lymphocyte subsets was significantly higher. After the treatment,CD3 and CD4 of the VMC group increased,while CD8 decreased. The ratio of CD4 / CD8 turned back to normal condition. Conclusion： Disturbance of immune regulatory function may occur in children with viral myocarditis. T lymphocyte subsets plays an important role in the morbidity,development and prognosis of viral myocarditis.

关 键 词：病毒性心肌炎 T细胞亚群 免疫损害 预后 儿童 

分 类 号：R542.21[医药卫生—心血管疾病]