莫沙必利联合不同益生菌对早产儿生长发育及胃肠功能的影响  

Effect of Mosapride Combined with Different Probiotics on Growth and Development and Gastrointestinal Function of Preterm Infants

作　　者：高龙军[1] 邢子茂 焦德清[2] 

机构地区：[1]广元市第三人民医院儿内科,四川广元628001 [2]广元市中心医院儿科,四川广元628001

出　　处：《医学综述》2016年第8期1655-1658,共4页Medical Recapitulate

摘　　要：目的观察莫沙必利联合不同益生菌对早产儿生长发育及胃肠功能的影响。方法选取2013年1月至2014年12月广元市第三人民医院收治的88例早产儿为研究对象,根据随机数字表分为观察组和对照组,各44例。两组早产儿均给予常规护理并莫沙必利治疗,观察组早产儿在常规治疗基础上给予口服枯草杆菌肠球菌二联活菌治疗,每次1 g,每日2次,用至出院;对照组在常规治疗基础上给予口服酪酸梭菌双歧杆菌二联活菌治疗,每次0.5 g,每日2次,用至出院。比较两组早产儿生长发育、营养摄取、喂养不耐受、黄疸消退时间及并发症等方面的差异。结果两组早产儿住院期间平均体质量增长速度、早产儿宫外生长发育迟缓发生率比较差异无统计学意义(P>0.05);两组每日奶量添加速度、第14日摄入奶量、全胃肠喂养开始时间及住院时间比较差异无统计学意义(P>0.05);两组喂养不耐受发生率、腹胀与呕吐时间、胃管留置时间比较差异无统计学意义(P>0.05)。两组早产儿住院期间初次排便时间、胎粪排尽时间、日平均大便次数比较差异无统计学意义(P>0.05)。观察组早产儿黄疸消退时间为(11.7±2.7)d,显著低于对照组的(13.0±2.2)d;住院第7日血清总胆红素水平为(132±25)μmol/L、第14日(61±10)μmol/L,均显著低于对照组的(151±32)μmol/L、(72±17)μmol/L,差异均有统计学意义(P<0.05)。观察组败血症发生率高于对照组[9.1%(4/44)比0.0%],差异有统计学意义(P<0.05)。结论枯草杆菌肠球菌二联活菌和酪酸梭菌双歧杆菌二联活菌分别联合莫沙必利均能有效防治早产儿胃肠功能紊乱,促进婴儿营养物质的吸收与生长发育;枯草杆菌肠球菌二联活菌联合莫沙必利退黄作用优于酪酸梭菌双歧杆菌二联活菌联合莫沙必利,而后者在降低早产儿败血症方面具有优势。Objective To observe the effect of mosapride combined with different probiotics on growth and development and gastrointestinal function of preterm infants. Methods Total of 88 premature infants admitted to Guangyuan Third People＇s Hospital from Jan. 2013 to Dec. 2014 were included in the study and divided into observation group and control group according to random number table method,each group with44 cases. All infants were given routine nursing and mosapride,based on which the observation group was given Bacillus subtilis ＋ Enterococcus dual probiotics,1 g / time,2 times / day,until discharge; the control group was given Clostridium butyricum ＋ Bifidobacterium dual probiotics,0. 5 g / time,2 times / day,until discharge. The growth and development indexes,nutritional intake indexes,feeding intolerance ratio,jaundice extinction time and complications of the two groups were compared. Results During hospitalization,average body quality growth,incidence of EUGR of the two groups had no statistically significant differences（ P〉0. 05）; daily milk add speed,14 d milk intake,full enteral feeding starting time and hospitalization of the two groups had no significant difference（ P〉0. 05）; feeding intolerance,abdominal distension and vomiting,stomach tube indwelling time also had no statistically significant differences（ P〉0. 05）. First defecation time,meconium discharge time,average daily stool frequencies of the two groups had no significant difference（ P〉0. 05）. The jaundice extinction time（ 11. 7 ± 2. 7） d,7 d serum total bilirubin level（ 132 ± 25） μmol / L,14 d serum total bilirubin level（ 61 ± 10） μmol / L of the observation group were all significantly lower than the control group＇s（ 13. 0 ± 2. 21） d,（ 151 ± 32） μmol / L,（ 72 ± 17） μmol / L（ P〉0. 05）. The incidence of septicemia of the observation group was higher than the control group[9. 1%（ 4 /44） vs 0. 0%,P〈0. 05].Conclusion Both bacillus subtilis ＋ enterococcus and clostridium buty

关 键 词：早产儿 益生菌 莫沙必利 生长发育 胃肠功能 

分 类 号：R722[医药卫生—儿科]