比阿培南与其他抗菌药物对某院临床分离致病菌的体外敏感性比较  

Comparison of in vitro antimicrobial activities of biapenem and other antibacterial agents against clinically pathogenic bacteria isolated from our hospital

作　　者：董婧[1,2] 朱慧[3] 沈振华[3] 李文艳[2] 刘艳辉[2] 姚佳晨[2] 陈西敬[1] 

机构地区：[1]中国药科大学药物代谢动力学研究中心,江苏南京210009 [2]上海市浦东新区公利医院药剂科,上海200135 [3]上海市浦东新区公利医院细菌室,上海200135

出　　处：《中国医院药学杂志》2016年第7期585-588,共4页Chinese Journal of Hospital Pharmacy

基　　金：上海医院药学科研基金(编号:2013-YY-01-08)

摘　　要：目的:比较研究比阿培南和其他抗菌药物的体外抗菌活性。方法:收集2015年1-5月某院分离的344株临床常见致病菌,采用纸片扩散法测定比阿培南和对照药(美罗培南、亚胺培南、厄他培南、氨曲南、左氧氟沙星、哌拉西林他唑巴坦、头孢他啶和头孢吡肟)对革兰阴性菌的敏感性,及比阿培南和对照药(美罗培南、左氧氟沙星、万古霉素、利奈唑胺、克林霉素、青霉素和呋喃妥因)对革兰阳性菌的敏感性。结果:比阿培南与美罗培南、亚胺培南、厄他培南、哌拉西林他唑巴坦对产和不产ESBL的大肠埃希菌和肺炎克雷伯菌、阴沟肠杆菌及其他肠杆菌的敏感率相仿,且差异无统计学意义(P>0.05),但比阿培南对铜绿假单胞菌的敏感率显著高于其他抗菌药物(P<0.05);比阿培南与美罗培南对甲氧西林敏感的金葡菌、耐甲氧西林的金葡菌、粪肠球菌和屎肠球菌的敏感率相仿,但显著低于万古霉素、利奈唑胺和呋喃妥因(P<0.001)。结论:与其他抗菌药物相比,比阿培南对某院临床分离的革兰阴性菌尤其是铜绿假单胞菌有较高的敏感率,但对鲍曼不动杆菌和肠球菌有较高的耐药率。OBJECTIVE To compare antimicrobial activities of biapenem and other antibacterial agents in vitro.METHODS A total of 344 isolates of clinically common pathogenic bacteria were collected from January to May 2015 in our hospital.Sensitive rates of biapenem,meropenem,imipenem,ertapenem,aztreonam,levofloxacin,piperacillin-tazobactam,ceftazidime and cefepime against gram-negative bacteria,and the sensitive rates of biapenem,meropenem,levofloxacin,vancomycin,linezolid,clindamycin,penicillin and macrodantin against gram-positive bacteria,were detected using K-B method.RESULTSSensitive rates of ESBL producing and non-producing E.coli,K.pneumoniae,E.cloacae and Enterobacteriumto biapenem,meropenem,imipenem,ertapenem and piperacillin-tazobactam were not significantly different（P〉0.05）,but biapenem was potent against P.aeruginosa（P〈0.05）.Sensitive rates of MSSA,MRSA,E.faecium and E.faecalis to biapenem and meropenem were similar,but lower than vancomycin,linezolid and macrodantin（P〈0.001）.CONCLUSION Compared with other antibacterial agents,biapenem has a high sensitivity against gram-negative bacteria,especially against P.aeruginosa,but a lower sensitivity against A.baumannii and Enterococcus.

关 键 词：比阿培南 革兰阴性菌 革兰阳性菌 敏感率 

分 类 号：R978.1[医药卫生—药品]