重型肝炎合并肺部曲霉菌感染临床诊治分析  

Clinical diagnosis and treatment of severe hepatitis complicated with pulmonary Aspergillusinfection

作　　者：吴翠萍[1] 董学军[1] 曹显刚[1] 杨谦[1] 夏德全[1] 

机构地区：[1]潍坊益都中心医院感染性疾病科,山东潍坊262500

出　　处：《中华医院感染学杂志》2016年第8期1703-1705,共3页Chinese Journal of Nosocomiology

基　　金：山东省自然科学基金资助项目(2014ZRB14474)

摘　　要：目的研究重型肝炎合并肺部曲霉菌感染的临床效果,为临床诊治工作提供一定的理论依据。方法选取医院2010年4月-2015年5月诊治的102例重型肝炎患者,依据是否存在真菌感染分为两组,无真菌感染患者为对照组68例,有真菌感染患者为观察组34例;对比两组患者临床资料,调查和统计患者的诊断结果、预后效果以及多种检查结果,数据采用SPSS 12.0软件进行统计分析。结果观察组患者的总胆红素、丙氨酸氨基转移酶水平等同于对照组,两组差异无统计学意义;所选的患者均应用>3周的抗菌药物治疗,观察组患者实施侵入性操作次数、应用碳青酶烯类抗菌药物以及应用糖皮质激素患者数量明显多于对照组,两组差异有统计学意义(P<0.05)。结论重型肝炎合并肺部曲霉菌感染的患者对其产生影响的因素,主要与侵入性操作次数、病情严重程度、碳青酶烯类抗菌药物以及并发症的出现、应用糖皮质激素等多种因素密切相关。OBJECTIVE To observe the effect of clinical diagnosis and treatment of severe hepatitis complicated with pulmonary Aspergillus infection so as to provide certain theoretical basis for clinical diagnosis and treatment.METHODS A total of 102 patients with severe hepatitis who were treated in the hospital from Apr 2010 to May2015were enrolled in the study,68 patients without infections were assigned as the control group,and 34 patients were set as the observation group.The clinical data were compared between the two groups of patients,the results of diagnosis,prognosis,and results of examinations were investigated,and the statistical analysis of data was performed with the use of SPSS 12.0software.RESULTS The levels of total bilirubin and alanine aminotransferase of the observation group were basically as same the those of the control group,and there was no significant difference between the two groups.All the enrolled patients were treated with antibiotics for more than 3weeks;the frequency of implementation of invasive operations,cases of use of carbapenems,and cases of use of glucocorticoids were significantly more in the observation group than in the control group（P〈0.05）.CONCLUSION The major influencing factors for the pulmonary Aspergillus infection in the patients with severe hepatitis include the frequency of invasive operation,severity of disease,use of carbapenems,emergence of complications,and use of glucocorticoids.

关 键 词：慢性重型肝炎 肺部曲霉菌感染 诊治分析 

分 类 号：R512.6[医药卫生—内科学]