重症细菌感染患者血清降钙素原联合C-反应蛋白水平检测的应用研究  

Value of combined detection of serum procalcitonin and C-reactive protein in patients with severe bacterial infections

作　　者：皮白雉[1,2] 方强[1] 姚小英 徐网兰 姚钧 宣娟娟 

机构地区：[1]浙江大学附属第一医院重症医学科,浙江杭州310003 [2]武警浙江总队嘉兴医院重症医学科,浙江嘉兴314000

出　　处：《中华医院感染学杂志》2016年第8期1718-1720,共3页Chinese Journal of Nosocomiology

基　　金：浙江省卫生厅基金资助项目(2013KYB212)

摘　　要：目的探讨联合检测血清降钙素原(PCT)联合C-反应蛋白(CRP)检测,对重症细菌感染患者诊断及预后的评价,为临床治疗提供参考依据。方法选择自2013年2月-2015年4月于医院接受诊断和治疗的重症细菌感染患者60例为观察组;同期选择健康体检者的60名为对照组,利用电化学发光法检测两组的PCT和CRP水平,比较两组受试者阳性率及临床指标,数据采用SPSS 19.0软件进行统计分析。结果观察组患者PCT和CRP阳性率分别为93.3%和76.6%,对照组为5.0%和18.3%,观察组患者PCT和CRP阳性率明显高于对照组,差异有统计学意义(P<0.05);治疗后PCT、CRP水平与治疗前相比明显降低,且治疗后72h较48h更低,差异有统计学意义(P<0.05)。结论重症细菌感染患者的PCT和CRP水平均显著上升,PCT和CRP可作为重症细菌感染诊断的灵敏指标,对于PCT和CRP的动态监测有助于重症细菌感染预后判断。OBJECTIVE To explore the value of combined detection of serum procalcitonin（PCT）and C-reactive protein（CRP）in diagnosis of severe bacterial infections and evaluation of prognosis so as to provide guidance for clinical treatment.METHODS Totally 60 patients who were diagnosed with severe bacterial infections and treated in the hospital from Feb 2013 to Apr 2015 were chosen as the observation group,meanwhile,60 healthy people who received the physical examination were set as the control group.The levels of PCT and CRP were detected by using electrogenerated chemiluminescence method,the positive rates and clinical indicators were observed and compared between the two groups of participants,and the statistical analysis of data was performed with the use of SPSS 19.0software.RESULTS The positive rate of PCT of the observation group was 93.3%,significantly higher than 5.0% of the control group;the positive rate of CRP of the observation group was 76.6%,significantly higher than 18.3% of the control group,and there was significant difference（P〈0.05）.The levels of PCT and CRP were significantly lower after the treatment than before the treatment,which were even lower after the treatment for 72 hours than after the treatment for 48 hours,and there was significant difference（P〈0.05）.CONCLUSION The levels of PCT and CRP of the patients with severe bacterial infections are remarkably elevated.The PCT and CRP can be used as sensitive indicators for diagnosis of the severe bacterial infections,and the dynamic monitoring of PCT and CRP may facilitate the estimation of prognosis of the severe bacterial infections.

关 键 词：血清降钙素原 C-反应蛋白 重症细菌感染 

分 类 号：R446.6[医药卫生—诊断学]