透明质酸与癌症的研究进展  

Research progress on hyaluronan and cancer

作　　者：柯春林[1] 程晨[1] 曾卫国[1] 

机构地区：[1]蚌埠学院生物与食品工程系,安徽蚌埠233030

出　　处：《应用化工》2016年第4期737-741,746,共6页Applied Chemical Industry

基　　金：安徽省自然科学基金项目(1408085MH209);高校优秀青年人才支持计划重点项目(gxyqZ D2016360);蚌埠学院学术技术带头人后备人选培养计划项目(院字〔2014〕182)

摘　　要：透明质(HA)是由D-葡萄糖醛酸和N-乙酰-D-葡糖胺两种单糖重复组成的线性多糖。HA在进化上十分保守并在细胞外基质(ECM)、细胞表面甚至细胞内部大量表达。作为一个简单的多糖,HA具有多种生物学功能,HA与各种蛋白质或糖蛋白组织成ECM维持着组织的动态平衡。HA能与细胞表面受体结合,激活不同的信号转导通路,从而控制着肿瘤的发展和转移。从基质的生物学角度阐述了HA的特性,首先引入HA潜在的生物合成和生物降解原则,接着介绍了HA与多种不同蛋白和蛋白多糖的相互作用,然后阐述了HA在癌症中的作用,以期对HA潜在的生物学功能及作用机制有更深的了解。Hyaluronan（ HA） is a linear polysaccharide with disaccharide repeats of D-glucuronic acid and N-acetyl-D-glucosamine. It is evolutionarily conserved and abundantly expressed in the extracellular matrix（ ECM）,on the cell surface and even inside cells. Being a simple polysaccharide,HA exhibits an astonishing array of biological functions. HA interacts with various proteins or proteoglycans to organize the ECM and to maintain tissue homeostasis. Binding of HA with cell surface receptors activates various signaling pathways,which regulate tumor progression and metastasis. The properties of HA from a matrix biology perspective were illustrated by first introducing the principles underlying the biosynthesis and biodegradation of HA,as well as the interactions of HA with various proteins and proteoglycans. It next highlights the roles of HA in cancer. A deeper understanding of the mechanisms underlying the roles of HA in various physiological processes can provide new insights and tools for the activity of HA.

关 键 词：透明质酸 透明质酸酶 透明质酸结合蛋白 肿瘤 癌症 

分 类 号：TQ281.1[化学工程—有机化工]