复发性外阴阴道假丝酵母菌病FUNGUS-7药敏研究  

In vitro susceptibility of candida albicans isolated from recurrentvulvovaginal candidiasis to seven antifungal agents

作　　者：李赛男[1] 许妙玲[1] 李红宾[2] 祁文瑾[1] 

机构地区：[1]昆明医科大学第一附属医院妇产科,云南昆明650032 [2]昆明医科大学第一附属医院皮肤科,云南昆明650032

出　　处：《皮肤病与性病》2016年第2期97-99,共3页Dermatology and Venereology

基　　金：国家自然科学基金资助项目(编号:81160076);云南省中青年学术技术带头人后备人才培养项目(编号:2012HB029)

摘　　要：目的明确复发性外阴阴道假丝酵母菌病(Recurrent Vulvovaginal candidiasis,RVVC)致病白假丝酵母菌对7种常用抗真菌药物的敏感性差异。方法以FUNGUS-7真菌药敏试剂盒对已确定的213株白假丝酵母菌致病菌株进行2种多烯类药物、4种唑类药物和5-氟胞嘧啶共七种抗真菌药的体外药物敏感试验;结果 RVVC组致病白假丝酵母菌对7种抗真菌药物的敏感性依次为:制霉菌素>两性霉素B>5-氟胞嘧啶>益康唑>咪康唑>氟康唑>伊曲康唑;VVC组致病白假丝酵母菌对7种抗真菌药物的敏感性依次为:两性霉素B>制霉菌素>5-氟胞嘧啶>咪康唑>益康唑>氟康唑>伊曲康唑;RVVC组对制霉菌素和咪康唑的敏感性显著高于VVC组(P<0.05);结论 RVVC和VVC致病白假丝酵母菌对抗真菌药的敏感性大体一致,RVVC治疗首选制霉菌素,VVC治疗首选制霉菌素或两性霉素B。Objective To determine in vitro susceptibilities of Candida albicans isolated from RVVC （Recurrent Vulvovaginal candidiasis） and VVC （ Vulvovaginal candidiasis） patients, to seven kinds of antifungal drugs. Methods Antifungalsusceptibility test in vitro was completed by using BIOKONT fungus kits（FUNGUS-7） , which incliuding two kinds of Polyene antifungul drugs, four kinds of azoles and 5-fluoroctosine. Results The isolates from RVVC showed the antifungal susceptibility order as nystatin〉amphotericinB〉5-fluorocytosine〉 econaole〉miconazole〉fluconale〉itraconale, while those from VVC showed the antifungal susceptibility order as amphotericin B 〉nystatin 〉5-fluorocytosine 〉 miconazole 〉 econaole 〉 fluconale 〉 itraconale. The isolates from RVVC were more susceptible to nystatin and miconazole than those from VVC （P〈O. 05） ;Conclusion The antifungal susceptibilities of C. albicans from RVVC and VVC are similar, and nystatin is the better choice for RVVC patients, while nystatin and amphotericin B was recommended in VVC treat-ment,

关 键 词：外阴阴道假丝酵母菌病 复发性 药物敏感性 

分 类 号：R978.5[医药卫生—药品] R711.31[医药卫生—药学]