血清卵泡抑素样蛋白1表达和冠心病的相关性研究  

The Preliminary Study on Follistatin-like Protein 1 and Coronary Artery Disease

作　　者：刘长召 王玲 陈文江[2] 

机构地区：[1]恩施土家族苗族自治州中心医院心内科,恩施445000 [2]广东医学院研究生学院,湛江524023

出　　处：《成都医学院学报》2016年第2期224-228,共5页Journal of Chengdu Medical College

摘　　要：目的探讨血清卵泡抑素样蛋白1（FSTL1）与冠心病（CAD）发生发展的关系。方法纳入CAD患者207例,分为AMI组（n=72）、不稳定性心绞痛组（UAP组,n=65）、慢性稳定性冠心病组（SCAD组,n=70）,同时以CAG阴性的住院患者60例作为对照组,采静脉血行ELISA检测FSTL1和转化生长因子-β1（TGF-β1）表达。结果 4组患者在年龄、性别、基本病史方面较为一致（P〉0.05）,血肌酐、血糖、甘油三酯等生化检查比较,差异无统计学意义（P〉0.05）,而4组间总胆固醇和低密度脂蛋白水平比较,差异有统计学意义（P〈0.05）;AMI组与UAP组血浆FSTL1和TGF-β1表达明显较对照组升高（P〈0.05）,而SCAD组与对照组比较,差异无统计学意义（P〉0.05）,FSTL1和TGF-β1的Pearson相关系数为0.8932（P〈0.001）;AMI患者中3支血管病变者血浆FSTL1表达较双支病变和单支病变明显升高（P〈0.001）,且双支病变患者血浆FSTL1表达较单支病变患者也明显升高（P〈0.05）;FSTL1的ROC曲线下面积为0.99,95%CI（0.98～1.00）（P〈0.001）。结论 FSTL1可能与CAD发病有关,且与心肌梗死程度呈正比,并可能作为心肌损伤的生物标志物。Objective To study the relationship between Follistatin-like protein 1（FSTL1）and the coronary artery disease（CAD）.Methods 207 CAD patients were divided into AMI group（n=72）,unstable angina pectoris group（UAP group,n=65）and the stable chronic CAD group（SCAD group,n=70）.Meanwhile,the CAG negative hospitalized 60 patients were recruited as control group.FSTL1 and TGF-β1were detected in their plasma in ELISA.Results There were no statistical differences in age,gender and basic history in these groups;plasma FSTL1 and TGF-β1expression in AMI and UAP groups were significantly higher than the control group（P0.05）,while there were no statistical differences in SCAD group（P〈0.05）;the Pearson correlation coefficient in FSTL1 and transforming growth factor-β1（TGF-β1）was 0.8932（P0.001）;the expression of plasma FSTL1 in 3vascular lesions in AMI cases were increased significantly than 2vascular lesions and 1vascular lesion（P〈0.001）,and FSTL1 expression of 2vascular lesions cases were significantly higher than 1vascular lesion（P〈0.05）;ROC curve analysis showed that the area under curve of FSTL1 was 0.99（95% CI：0.98 to 1.00,P0.001）.Conclusion FSTL1 may participate in mechanism of CAD,and may serve as biomarkers of myocardial injury.

关 键 词：血清卵泡抑素样蛋白1 冠心病 TGF-Β1 生物标志物 

分 类 号：R541.4[医药卫生—心血管疾病]