复方甘草酸苷联和多烯磷脂酰胆碱治疗小儿急性肝功能损伤的临床效果及其护理  

Effects and nursing care of compound glycyrrhizin union and polyene phosphatidylcholine in treatment of children with acute liver injury

作　　者：张磊[1] 

机构地区：[1]中国医科大学附属盛京医院小儿消化内科,辽宁沈阳110004

出　　处：《中国肝脏病杂志（电子版）》2016年第1期81-84,共4页Chinese Journal of Liver Diseases：Electronic Version

摘　　要：目的探讨复方甘草酸苷联和多烯磷脂酰胆碱在小儿急性肝功能损伤患儿中的临床治疗效果及护理方法。方法选取2013年4月至2015年3月中国医科大学附属盛京医院诊治的80例小儿急性肝功能损伤患儿资料进行分析,采用随机数字方法将患儿分为对照组和试验组,入选患儿均实施临床干预护理,对照组采用多烯磷脂酰胆碱治疗,试验组在对照组基础上联合复方甘草酸苷治疗,比较两组疗效。结果试验组35例显效,3例好转,总有效率为95%,显著高于对照组(总有效率为85%)(P=0.04);试验组护理38例满意,满意率为95%,显著高于对照组(满意率为65%)(P=0.037);两组治疗前ALT、AST、A/G以及TBil差异不显著(P>0.05);试验组治疗后ALT、AST等指标显著低于对照组(P<0.05);试验组治疗后A/G及TBil指标显著高于对照组(P<0.05)。结论小儿急性肝功能损伤中采用复方甘草酸苷联和多烯磷脂酰胆碱治疗效果理想,且患儿治疗时实施临床干预护理能够进一步提高临床疗效,值得推广使用。Objective To investigate the effects and nursing care of compound glycyrrhizin union and polyene phosphatidylcholine in treatment of children with acute liver injury. Methods Data of 80 children with acute liver injury from April 2013 to March 2015 in Shengjing Hospital of China Medical University were analyzed and divided into control group and experimental group according to random number method. All children were implemented clinical nursing intervention. The control group were treated with polyen.e~ phosphatidylcholine and the experimental group were treated with compound liquorice anhydride combined with phosphatidylcholine. The efficacy of two groups were compared, Results In the experimental group, 35 cases were cured, 3 cases improved, the total effective rate was 95%, which was significantly higher than that of control group （85%） （P = 0.04）. The satisfaction rate of experimental group was 95% （38 cases）, which was significantly higher than that of the control group （65%） （P = 0.037）. There were no significant difference on ALT, AST, A/G and TBil index （P = 0.053） before treatment. After treatment, the ALT, AsT and other indicators in the experimental group were significantly lower than those of the control group （P 〈 0.05）. After treatment, the A/G and TBil in the experimental group were significantly higher than those of the control group （P 〈 0.05）. Conclusions Effect of compound licorice acid anhydride and polyene phosphatidylcholine on pediatric acute liver injury is ideal, and the implementation of clinical nursing intervention can improve clinical curative effect and it is worthy promotion.

关 键 词：复方甘草酸苷 多烯磷脂酰胆碱 肝功能损伤 急性 治疗效果 护理 

分 类 号：R725.7[医药卫生—儿科]