利培酮中盐酸羟胺的柱前衍生化-GC法测定  

Determination of Hydroxylamine Hydrochloride in Risperidone by GC with Pre-column Derivation

作　　者：丁宏伟[1] 陈国广[1] 任丽莉[1] 高盼[1] 

机构地区：[1]南京工业大学药学院,江苏南京211816

出　　处：《中国医药工业杂志》2016年第4期454-456,共3页Chinese Journal of Pharmaceuticals

摘　　要：建立了柱前衍生化气相色谱法测定利培酮中的盐酸羟胺。以环己酮作为衍生化试剂,二氯甲烷为萃取溶剂,采用Agilent HP-5毛细管柱,程序升温,气化室温度220℃,氢火焰离子检测器（FID）温度280℃。盐酸羟胺在5.4~12.6μg/ml范围内线性关系良好,平均回收率为100.6%,RSD为3.44%。A GC method was established for the determination of hydroxylamine hydrochloride in risperidone by pre-column derivation with cyclohexanone. Dichloromethane was used as the extraction reagent. An Agilent HP-5 capillary column was used, with programmed temperature, at the injection port temperature of 220 ℃ and the FID temperature of 250 ℃. It was linear in the concentration range of 5.4—12.6 μg/ml. Its recovery was 100.6%, with RSD of 3.44%.

关 键 词：利培酮 盐酸羟胺 柱前衍生化 气相色谱 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.71[化学工程—制药化工]