岩白菜素偶氮衍生物的制备  

Synthesis of Bergenin Azo Derivatives

作　　者：段文越[1] 郭巍怡 邹澄[1] 赵庆[2] 杨为民[1] 陈晨[1] 

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室,云南昆明650500 [2]云南中医学院中药学院,云南昆明650500

出　　处：《云南中医学院学报》2016年第2期25-29,共5页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81160388);云南省教育厅科学研究基金项目(2014J042)

摘　　要：目的设计合成岩白菜素偶氮衍生物。方法对岩白菜素7位进行结构改造,通过重氮化偶合反应制备其衍生物,并通过波谱法进行结构鉴定。结果制备了7个岩白菜素偶氮衍生物,其中7个化合物均为新化合物。结论这些化合物的合成为大量合成同类衍生物并进行药理活性筛选奠定了研究基础,为岩白菜素的深入研究与开发利用提供新的方法。Objective To design and synthesize bergenin azo derivatives. Methods A series of bergenin azo derivatives were synthesized by diazo coupling reaction. After purification the compounds were characterized by NMR. Results Seven derivatives were obtained and all of them were new compounds. Conclusions These compounds establish the research foundation for similar derivatives and pharmacological study. This provides a new approach for development and further research of bergenin.

关 键 词：岩白菜素 含氮衍生物 重氮化偶合反应 

分 类 号：R284.3[医药卫生—中药学]