异甘草酸镁联合拉米呋啶治疗重型乙肝临床疗效观察  

Observation of curative effect of magnesium isoglycyrrhizinate combined with lamivudine in treatment of severe hepatitis B

作　　者：龚诗[1] 

机构地区：[1]广东省高州市人民医院感染内科,广东高州525200

出　　处：《中国医药科学》2016年第5期94-96,103,共4页China Medicine And Pharmacy

摘　　要：目的观察异甘草酸镁联合拉米呋啶治疗重型慢性乙型肝炎的疗效分析。方法选取我院2010年1月~2013年1月我院收治的200例慢性乙型肝炎患者作为研究对象,将200例慢性乙型肝炎患者随机分成两组,对照组使用拉米呋啶进行治疗,观察组用异甘草酸镁和拉米呋啶联合治疗。观察治疗前后两组在乙型肝炎病毒学指标HBV-DNA、血清学检测指标乙肝＂两对半＂、肝细胞损伤程度的检测：包括丙氨酸氨基转移酶（ALT）和天门冬氨酸氨基转移酶（AST）的变化。结果治疗8周时,观察组和对照组的HBV-DNA值均有下降,但血清中HBV-DNA比较差异无统计学意义。治疗16、24周时,观察组和对照组的HBV-DNA值均有明显下降,两组的血清中HBV-DNA有统计学差异;两组患者在8,16,24周时血清中肝功能各项指标的变化值均有明显的差异,各项指标的变化差异有统计学意义;观察组改善肝功能的疗效明显优于对照组（P〈0.05）;两组患者治疗后8、16、24周时血清中毒物标志物HBV-DNA和Hbe Ag明显低于治疗前,且比较差异有统计学意义（P〈0.05）。结论联合应用异甘草酸镁联合拉米呋啶治疗重型慢性乙型肝炎的效果显著优于单纯使用拉米呋啶。Objective To observe the curative effect of magnesium isoglycyrrhizinate combined with lamivudine in treatment of severe chronic severe hepatitis B. Methods 20 patients with chronic hepatitis B who were admitted to our hospital from January 2010 to January 2013 were selected as research objects and they were randomly allocated to the control group and the observation group.The control group was received lamivudine treatment while the observation group was received the treatment of magnesium isoglycyrrhizinate combined with lamivudine.Hepatitis B virus index HBV-DNA,serological index hepatitis B＂ two half and half＂,detection of liver cell damages degree including changes of alanine aminotransferase（ALT） and aspartate aminotransferase（AST） before and after treatment of two groups were observed. Results At 8 weeks of treatment, HBV-DNA values of two groups were all significantly decreased.But difference in HBV-DNA of serum had no statistical significance. After 16 and 24 weeks of treatment,HBVDNA values of two groups were all significantly decreased.But difference in HBV-DNA of serum had no statistical significance.At 8 weeks, 16 and 24 weeks of treatment,changes in indexes of liver function in serum of patients in two groups all had significant difference.Difference in changes of every index had statistical significance.Curative effect of improving liver functions in the observation group was superior to that of the control group（P〈0.05）.At 8 weeks, 16 and 24 weeks after treatment,toxic markers such as HBV-DNA and Hbe Ag in serum were significantly lower than those before treatment.And comparative difference had statistical significance（P〈0.05）. Conclusion Magnesium isoglycyrrhizinate combined with lamivudine in treatment of severe chronic severe hepatitis B has more significant effect than single treatment of lamivudine.

关 键 词：异甘草酸镁 重型慢性乙型肝炎 肝功能 HBV-DNA 肝细胞损伤 

分 类 号：R521.62[医药卫生—内科学]