甲巯咪唑引发抗中性粒细胞胞质抗体相关性小血管炎的案例分析  

One case of methimazole-induced antineutrophil cytoplasmic antibody-associated vasculitis

作　　者：石雅丽[1] 朱立勤[2] 

机构地区：[1]南京医科大学附属南京儿童医院药学部,南京210008 [2]天津市第一中心医院药学部,天津300192

出　　处：《中国临床药理学杂志》2016年第8期742-743,共2页The Chinese Journal of Clinical Pharmacology

摘　　要：目的分析甲巯咪唑引发抗中性粒细胞胞质抗体相关性小血管炎的案例,为临床防治提供参考。方法患者因甲状腺功能亢进规律服用甲巯咪唑10mg,bid 1年余,因呼吸系统症状入院治疗,入院后发现该患者有咯血、血尿、肾功能不全等表现,分析该表现与用药的相关性。结果该临床表现很可能为甲巯咪唑引发的抗中性粒细胞胞质抗体相关性小血管炎。结论甲巯咪唑在治疗甲状腺功能亢进过程中可引发抗中性粒细胞胞质抗体相关性小血管炎。早期诊断和合理治疗是减少不良反应的关键。Objective To analyze one case of methimazole-induced antineutrophil cytoplasmic antibody-associated vasculitis and offer some advice for its prevention and treatment. Methods The patient was diagnosed with hyperthyroidism and had been given methimazole（10 mg bid）for 1 year. He was admitted to hospital due to respiratory symptoms and developed to hemoptysis,hematuresis,renal insufficiency after hospitalization. The relationship between clinical symptoms and drug-induced reactions were analyzed. Results The clinical symptoms were probably associated with methimazole-induced antineutrophil cytoplasmic antibody-associated vasculitis. Conclusion It may cause antineutrophil cytoplasmic antibody-associated vasculitis during methimazole therapy. Early diagnosis and rational management are the keys to reduce adverse drug reaction.

关 键 词：甲巯咪唑 不良反应 小血管炎 

分 类 号：R977.14[医药卫生—药品]