药物以微小RNA为靶点治疗心血管疾病的研究进展  

Research progress of drugs targeting on microRNA in the treatment of cardiovascular diseases

作　　者：杨瑞[1] 赵丹丹[1] 李雪连[1] 

机构地区：[1]哈尔滨医科大学药学院药理教研室,心血管药物研究教育部重点实验室,哈尔滨150086

出　　处：《中国临床药理学杂志》2016年第8期762-764,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81100134);哈尔滨医科大学药学院大学生创新创业训练计划基金资助项目(YXY2014014)

摘　　要：微小核糖核酸（microRNA）是长度约为20-24个核苷酸的微小RNA,参与了许多心血管疾病的病理过程,如心律失常、心力衰竭、心肌梗死、心肌纤维化等。近年来研究发现,microRNA可能成为心血管药物的潜在新靶点。本文围绕药物通过调节microRNA治疗心血管疾病的研究进行综述。MicroRNA is a kind of small RNA,about 20-24 nucleotides. It was involved in pathological process of many cardiovascular diseases,such as arrhythmia,heart failure,myocardial infarction,myocardial fibrosis and so on. Recently studies found that microRNA had become one potential drug target for the treatment of cardiovascular diseases. In this review,we summarized the research of drugs targeting on microRNA in treatment of cardiovascular diseases.

关 键 词：微小核糖核酸 心血管疾病 

分 类 号：R972[医药卫生—药品]