狗舌草对铅中毒小鼠排铅作用药效学研究  

Lead-Eliminating Function of Kennel Grass in Lead Poisoning Rats

作　　者：杨晨[1] 唐旗羚 刘金泳 陶紫 郭纪全[5] 王其友[6] 祝曙光[5] 高思远[7] 李佳虹[1] 王有娣[1] 潘雪刁[7] 高瑞萍[8] 王军业[9] 臧林泉[7] 

机构地区：[1]广东药学院中药学院,广东广州510006 [2]中山大学新华学院,广东广州510520 [3]广州市南沙中心医院药学科,广东广州511400 [4]佛山市南海区第二人民医院社区卫生科,广东佛山528251 [5]广东省人民医院呼吸内科,广东广州510080 [6]中山大学第三附属医院脊柱外科,广东广州51630 [7]广东药学院药科学院,广东广州510006 [8]广东药学院第一附属医院,广东广州510080 [9]中山大学肿瘤防治中心华南肿瘤学国家重点实验室,广东广州51630

出　　处：《广东化工》2016年第7期39-41,63,共4页Guangdong Chemical Industry

基　　金：广东省科技计划项目(No:2015A020211028);吴阶平基金会资助项目(No.320.6750.1208);广东省医学科研基金(No.A2013320)

摘　　要：本实验研究狗舌草水提取液对染铅小鼠的排铅药效学作用及狗舌草对重要器官组织的保护作用。方法：使用60只18~22 g合格昆明种小鼠,雄雌各半,按体重随机分组分为6组,自然饮食0.1%醋酸铅溶液连续15天,建立铅中毒小鼠模型。建模成功后,以灌胃的方式给予试药组小鼠狗舌草水提液,在给药30天后通过石墨炉原子吸收光谱仪测定试药组与模型组的血铅浓度,数据进行t检验;并进行组织切片观察狗舌草对重要器官组织的影响。结果：狗舌草水提液可以降低小鼠的血铅浓度,狗舌草水提液对染铅小鼠的肝脑肾组织没有破坏性损伤作用。结论：狗舌草水提液能够产生排铅药效学作用,并且没有对重要器官组织造成损害。Objective： this experiment studied the lead-excreting effect of kennel grass aqueous extracts to the lead intoxicated mice and the protective effect to vital organic tissues. Methods： Sixty 18-22 g qualified Kunming mice which were composed of male and female in equal were divided at random into six group by weight, which were taken a normally diet within 0.1 % lead acetic acid solution for 15 days in order to establish lead poisoning mice model. After the success of modeling, the mice were treated by means of dosing kennel grass aqueous extracts in i.g for thirteen days. The blood lead levels of drug group and control group graphite were tested by furnace atomic absorption spectrometer, and t-test for them was performed. Result： Biopsy observation indicated that kennel grass aqueous extracts had no destructive damage effect to vital organs. Conclusion： the kennel grass aqueous extracts can reduce the blood lead levels in mice and there is no damage to vital organic tissues.

关 键 词：狗舌草 铅中毒 排铅 

分 类 号：X503.1[环境科学与工程—环境工程]