成骨生长肽的生物学特征及构效关系研究进展  

A review of osteogenic growth peptide on biological characteristics and structure-activity relationship

作　　者：张腾[1,2] 侯宝龙[1] 赵金礼 刘建利[1] 

机构地区：[1]西北大学生命科学学院,陕西西安710069 [2]西安华澳丽康活性蛋白与多肽工程中心,陕西西安710054

出　　处：《中国药物化学杂志》2016年第2期146-153,159,共9页Chinese Journal of Medicinal Chemistry

摘　　要：成骨生长肽是具有促进成骨和刺激造血作用的多肽类生长因子,原肽由十四个氨基酸组成,碳端五肽是维持原肽全部活性的最短氨基酸序列。本文就成骨生长肽的生物学特征及构效关系进行综述。Osteogenic growth peptide （OGP） is an endogenous tetradecapeptide physiologically present in the blood circulation at micromolar concentrations. The structure-activity relationship revealed that C-terminal pentapeptide OGP（10-14） ,with the sequence of Tyr-Gly-Phe-Gly-Gly,is the minimal fragment keeping the full OGP-like activity. Its analogues could be used as bone anabolic agents and stimulators of hematopoiesis. This paper mainly introduces and analyzes some viewpoints on biological characteristics and structure activity relationship of OGP, also puts forward some our new views.

关 键 词：成骨生长肽 生物活性 构效关系 

分 类 号：R3411[医药卫生—基础医学]