生物节律基因非编码RNA调控机制  

Regulation of Circadian Gene by Non-coding RNAs

作　　者：王艳利[1] 曲丽娜[2] 李莹辉[1,2] 

机构地区：[1]西北工业大学生命科学学院,西安710072 [2]中国航天员科研训练中心,航天医学基础与应用国家重点实验室,北京100094

出　　处：《中国生物化学与分子生物学报》2016年第4期353-358,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家科技重大专项项目(No.2012ZX09J12201);中国航天员科研训练中心航天医学基础与应用国家重点实验室自主项目(No.SMFA13B02)~~

摘　　要：节律性的振荡不仅存在于生物节律中枢也存在于外周器官、组织及细胞中,其产生依赖于节律基因的转录、转录后及翻译后水平调控。近几年,生物节律转录后水平调控机制研究成为热点。非编码RNA(ncRNAs)调控组分小RNA(microRNA)与长链非编码RNA(lncRNA)作为参与转录后调控的重要分子,已有研究表明microRNA与lncRNA调控节律基因mRNA与蛋白的相位及振幅。本文概述microRNA与lncRNA参与昼夜节律中枢与外周调控的研究进展,为生物节律转录后调控机制的进一步研究提供参考。Mammalian circadian rhythm is observed not only at the central suprachiasmatic nucleus,but also throughout the peripheral organs,tissues and cells. The study of the regulation of circadian clock gene expression has focused on transcriptional,posttranscriptional and post-translational mechanisms. In recent years,new studies have focused on post-transcriptional regulation in the circadian system. miRNA and lncRNA,two important regulators of non-coding RNAs have been discovered to alter the phase and amplitude of rhythmic mRNA and protein expression in many organisms,tissues and cells. Here,we will provide an overview of current knowledge of miRNA and lncRNA regulation of the clock genes and clockcontrolled genes in suprachiasmatic nucleus and peripheral. These results might lay the foundation for further study of post-transcriptional regulation mechanism of circadian genes.

关 键 词：生物节律 节律基因 小RNA 长链非编码RNA 

分 类 号：Q78[生物学—分子生物学]