冠心病合并高尿酸血症患者心脏自主神经功能研究  

Study on cardiac autonomic nervous function of patients with coronary disease complicating hyperuricemia

作　　者：朱珲莹[1] 叶焕文[1] 温建炫[1] 

机构地区：[1]广东省中医院心功能室,广东广州510120

出　　处：《实用心电学杂志》2016年第2期112-115,共4页Journal of Practical Electrocardiology

基　　金：广东省中药局资助项目(20132157)

摘　　要：目的观察冠心病患者合并高尿酸血症与心脏自主神经功能的相关性。方法以我院确诊的168例冠状动脉粥样硬化性心脏病患者为研究对象,其中,合并高尿酸血症患者67例(HUA+组),其中男39例、女28例,平均(61.16±6.66)岁;不合并高尿酸血症的单纯冠心病患者101例(HUA-组),其中男66例、女35例,平均(61.96±5.51)岁。观察两组患者心率变异性的各项指标。结果冠心病合并高尿酸血症组比单纯冠心病组的SDNN、SDANN index、SDNN index、rMSSD指标均显著降低(P<0.05)。结论研究表明,高尿酸血症可加重冠心病患者心脏自主神经功能受损。Objective To observe the correlation between hyperuricemia and cardiac autonomic nervous function in patients with coronary disease. Methods Clinical data of 168 patients diagnosed with coronary disease were analyzed. Among those cases,there were 67 complicated with hyperuricemia（ group HUA ＋） with 39 males and 28 females at an average age of（ 61. 16 ± 6. 66）years old; there were 101 complicated without hyperuricemia（ group HUA-） with 66 males and 35 females at an average age of（ 61. 96 ± 5. 51） years old. Each index of heart rate variability（ HRV）in the two groups was observed. Results The HRV indices of SDNN,SDANN index,SDNN index and rMSSD in group HUA ＋ were significantly lower than those in group HUA-（ P〈0. 05）. Conclusion This paper reveals that hyperuricemia can aggravate cardiac autonomic nervous dysfunction in patients with coronary disease.

关 键 词：冠心病 高尿酸血症 心率变异性 心脏自主神经功能 

分 类 号：R541.4[医药卫生—心血管疾病] R540.41[医药卫生—内科学]