肝硬化患者脾切断流术后早期应用奥曲肽的效果观察  

Effect of early use of octreotide in cirrhotic patients undergoing splenectomy and devascularization

作　　者：胡洪涛[1] 唐哲[1] 万仁瑞 任浩[1] 李向阳[1] 吴阳[1] 赵永福[1] 

机构地区：[1]郑州大学第一附属医院肝胆外科,河南郑州450052

出　　处：《河南医学研究》2016年第3期407-409,共3页Henan Medical Research

摘　　要：目的观察肝硬化门脉高压症患者脾切断流术后早期应用奥曲肽的效果。方法对65例行脾切断流术治疗的肝硬化门脉高压症患者的临床资料进行回顾性分析,将术后早期应用奥曲肽的29例患者设为观察组,未应用奥曲肽的36例患者设为对照组。观察两组患者术后血红蛋白(Hb)、腹腔引流液、尿量的变化,记录两组术后输血例数及输血量。结果与对照组相比,观察组患者术后第1、3、5、7天Hb水平明显升高,腹腔引流液明显减少,尿量明显增多(P<0.05)。对照组术后有2例因Hb偏低给予输血,观察组均未输血。结论对于行脾切断流术治疗的肝硬化门脉高压症患者,术后早期应用奥曲肽可降低门脉压力,减少创面渗血,降低术后输血率,减少腹腔积液的形成。Objective To investigate the effect of early use of octreotide in cirrhotic patients undergoing splenectomy and devascularization. Methods The clinical data of 65 cirrhosis patients with portal hypertension undergoing splenectomy and devascularization were retrospectively analyzed. All the patients were divided into observation group（ n = 29） and control group（ n =36） according to whether or not using octreotide after operation. Hemoglobin（ Hb）,ascites,urine volume on postoperative day（ POD） 1,3,5 and 7 were compared between observation group and control group. Results Compared with control group,the levels of hemoglobin and urine volume on POD 1,3,5,7 were significantly increased（ P 〈 0. 05）,and ascites was significantly lower（ P 〈 0. 05） in observation group. Conclusion The early use of octreotide after splenectomy and devascularization in cirrhotic patients with portal hypertension can reduce portal vein pressure and the volume of postoperative ascites,also prevent bleeding of surgical field.

关 键 词：奥曲肽 脾切断流术 肝硬化 腹腔积液 

分 类 号：R657.6[医药卫生—外科学]