酪氨酸与乙酰唑胺对高原移居者负荷运动后肺功能与血氧饱和度的干预作用  

EFFECTS OF TYROSINE AND ACETAZOLAMIDE ON LUNG FUNCTION AND BLOOD OXYGEN SATURATION FOLLOWING LOADED EXERCISE AT HIGH ALTITUDE

作　　者：马勇[1] 哈振德[1] 王伟[1] 张西洲[1] 朱永安[1] 崔建华[1] 张芳[1] 张素萍[1] 

机构地区：[1]新疆军区高山病研究所,844900

出　　处：《高原医学杂志》2002年第2期9-11,共3页Journal of High Altitude Medicine

摘　　要：目的 :探讨酪氨酸与乙酰唑胺对高原移居者负荷运动后肺功能及血氧饱和度的影响 ,为药物改善和提高低氧环境下人脑 -体作业能力提供依据 ;方法 :随机选择驻守海拔 3 70 0m6个月的男性汉族健康青年 3 0名 ,甲组 :口服安慰剂 (自制炒面胶囊 ) 1 0人 ;乙组 :口服酪氨酸 1 0人 ,丙组 :口服乙酰唑胺 1 0人 ;连续服药 1 5天 ,于服药前、服药 1 5天后、停药 1 0天后三阶段采用EGM型脚踏功量仪进行负荷运动 (负荷指标 :2 2 5W :P1 75～1 80次 /分 )运动后 5分钟检测SaO2 并进行肺功能测验 ;结果 :服药前运动前甲、乙、丙组的SaO2 显著大于服药前运动后、服药 1 5天运动后和停药 1 0天后运动后甲、乙、丙组的SaO2 (P <0 .0 1 ) ,服药 1 5天运动后及停药 1 0天运动后乙、丙组SaO2 显著大于甲组 (P <0 .0 5) ;服药 1 5天运动后、停药 1 0天运动后乙、丙组的SaO2 显著大于服药前运动后甲、乙、丙组的SaO2 (P <0 .0 5) ;服药前运动前、服药前运动后、服药 1 5天运动后、停药 1 0天运动后的肺功能参数甲、乙、丙三组交叉比较无显著意义 (P >0 .0 5) ;结论 :酪氨酸与乙酰唑胺均能显著提高低氧条件下负荷运动后的SaO2 ,可能是通过改善和调节氧的弥散和氧的运输或氧利用的途径来完成的。Objective:To study the effects of tyrosine and acetazolamide on lung function and blood oxygen saturation(SaO 2) following loaded exercise at high altitude.Method:30 subjects were random divided into A group( placebo),B group (tyrosine) and C group(acetazolamide) who have stayed 3 700 m altitude for 6 months,and constantly pedalled the EGM efficiency-bicycle as loaded exercise. (indexes: efficiency 225W, heart rate 170～180 bpm), to determine their SaO 2 and lung function before and after taking medicine for 15 days,and the 10th day while they had stopped.Results:The SaO 2 which have gained at rest were higher than that after exercise,for 15 days and the 10th day (P<0.01).Ta king medicine for 15 days and the 10th while they had stopped, the SaO 2 in medicine/s group were increased (P<0.05),and also higher than that before taking medicine (P< 0.05 ), but the lung function has no discrepancy (P>0.05).Conclusion:Both tyrosine and acetazolamide could improve the SaO 2 following loaded exercise at high altitude.

关 键 词：酪氨酸 乙酰唑胺 高原 负荷运动 肺功能 血氧饱和度 干预 低氧 

分 类 号：R594.3[医药卫生—内科学]