荷移分光光度法测定一水合磷酸西他列汀的含量  

Spectrophotometric Determination of Sitagliptin Phosphate Monohydrate Based on Charge-transfer Reaction

作　　者：张志华[1] 

机构地区：[1]辽宁工业大学化学与环境工程学院,辽宁锦州121001

出　　处：《化学世界》2016年第4期193-195,共3页Chemical World

摘　　要：在乙醇介质中,一水合磷酸西他列汀与红紫素在室温中放置15～30 min,二者可以形成1∶1型荷移络合物,其λmax为520nm,表观摩尔吸光系数为1.93×10^3 L/（mol·cm）,线性范围为0.031～0.209g/L,线性回归方程为A=3.104 5C＋0.144 2,相关系数R为0.999 1,相对标准偏差为1.32%（n=6）。实验结果用于捷诺维片含量的测定,结果满意。Sitagliptin phosphate monohydrate can react with urorrhodin to form 1∶1complex after being placed in room temperature for 15～30min,which gives a maximum absorption peak at 520 nm.The molar absorptivity of the complex was 1.93×10^3 L/（mol·cm）and the linear range was 0.031～0.209g/L.The linear equation was A =3.104 5 C＋0.144 2 R=0.999 1,and correlation coefficient（RSD）was1.32%（n=6）.Good results were obtained,when it was applied to the determination of Januvia tablets.

关 键 词：一水合磷酸西他列汀 荷移反应 分光光度法 

分 类 号：O626.4[理学—有机化学]