某医院临床分离病原菌及其耐药性研究  

Study on distribution and antimicrobial resistance of clinical isolates in a hospital

作　　者：郭青青[1] 

机构地区：[1]首都医科大学附属北京友谊医院,北京100050

出　　处：《中国消毒学杂志》2016年第4期326-328,共3页Chinese Journal of Disinfection

摘　　要：目的研究某医院临床分离病原菌种类分布及其耐药性情况,为防控医院感染和合理选择抗菌药物提供参考。方法采用细菌分离鉴定技术和药敏试验方法,对某三级甲等教学医院2014年度住院患者送检病原学标本进行病原菌检测与结果分析。结果该医院全年从患者送检病原学标本中共检出病原菌4 976株,其中革兰阴性杆菌占63.60%,革兰阳性球菌占35.11%和真菌占2.29%。医院感染患者标本分离病原菌中,以革兰阴性菌构成比为53.94%,革兰阳性菌构成比为30.57%,真菌占15.49%。医院感染病原菌中以铜绿假单胞菌、鲍曼不动杆菌、大肠埃希菌和肺炎克雷伯菌分居前4位。结论医院感染病原菌中以铜绿假单胞菌居首位,多重耐药菌比例明显增加,应重点防范多重耐药菌的蔓延。Objective To compare the distribution and antimicrobial resistance in clinical isolates and hospital- acquired infection isolates, for providing a basis for rational use of antibiotic prevention and controlling of nosocomial infections in clinical practice. Methods Kirby - Bauer method and automated systems were employed to study the isolates antimicrobial resistance. Results A total of 4862 no duplicated clinical isolates were collected in 2014, mong which the gram negative organisms accounting for 64.07% （3115/4862）, gram positive organisms for 33.59% （1747/4862） and fungus for 2. 35% （114/4862）. In hospital - acquired infection isolates , the gram negative organisms accounting for 53.94%, the gram positive organisms for 30.57%, and fungus for 15.49%. Pseudomonas aeruginosa, Escherichia coli, Acinetobacter bau- mannii and Klebsiella pneumonia were ranked in fourth in isolates hospital - acquired. Conclusion Pseudomonas aerugi- nosa strains rank first, which increasing the proportion of multi - drug resistant bacteria in this hospital. It is important to conduct and strengthen monitoring of multi - drug resistant bacteria for prevention and control of nosocomial infections.

关 键 词：病原菌 多重耐药菌 医院感染 监测 

分 类 号：R378[医药卫生—病原生物学]