微小RNA对树突状细胞功能的影响及在脓毒症中的作用  

The effect of microRNAs on dendritic cells function and its role in sepsis

作　　者：王勇涛[1] 柴艳芬[1] 姚咏明[2] 

机构地区：[1]天津医科大学总医院急救中心,天津300052 [2]解放军总医院第一附属医院创伤研究中心,北京100048

出　　处：《中华急诊医学杂志》2016年第4期534-538,共5页Chinese Journal of Emergency Medicine

基　　金：国家自然科学基金（81130035,81372054）;国家重点基础研究发展计划项目（2012CB518102）

摘　　要：微小RNA是一种进化上高度保守的非编码RNA，主要通过抑制蛋白质的翻译来调控基因表达进而影响细胞的命运及功能。众多资料表明miRNAs可调控免疫细胞的分化、功能及凋亡进而维持机体的免疫平衡。树突状细胞作为重要的抗原提成细胞，其功能及数量的改变在脓毒症的免疫紊乱中具有重要作用。本文将主要综述miRNAs对树突状细胞免疫功能及凋亡的影响及在脓毒症中的潜在作用。MicroRNAs （ miRNAs ） , a highly conserved and non coding RNA, modulates gene expression via inhibiting the translation of protein and thereby influences cell fate and function.A large body of literature demonstrates that miRNAs plays a critical role in the maintenance of immune homeostasis through modulating immune cell differentiation, function as well as apoptosis.As important antigen presentation cells, dendritic cells （ DCs） play a central role in the initiation and control of the adaptive immune response in the peripheral lymphatic system.Uncontrolled inflammatory response and immunosuppressive response followed by tissue and organ dysfunction were associated with DC loss and apoptosis after septic challenge.This review will focus on the effect of miRNAs on DC function and apoptosis, and its potential role in sepsis.

关 键 词：脓毒症 微小RNA 树突状细胞 

分 类 号：R459.7[医药卫生—急诊医学]