射干提取物对慢性咽炎家兔血清中白细胞介素-4和免疫球蛋白E表达的影响  

Effects of Rhizoma Belamcandae Extracts on the Expression of IL-4 and IgE in Rabbits with Experimentally Induced Chronic Pharyngitis

作　　者：尤献民[1] 邹桂欣[1] 赵金明[1] 王光函[1] 李国信[1] 

机构地区：[1]辽宁省中医药研究院,辽宁沈阳110034

出　　处：《中国药业》2016年第7期3-4,共2页China Pharmaceuticals

基　　金：国家"十二五"重大新药创制项目"中药新药临床技术平台评价研究技术平台";项目编号:2012zx09303-017;国家自然基金资助项目;项目编号:81273927;国家临床重点专科建设项目经费资助;国家中医药管理局临床中药学重点学科;辽宁中医药大学杏林学者青蓝工程

摘　　要：目的观察射干提取物用于慢性咽炎家兔血清中白细胞介素-4(IL-4)和免疫球蛋白E(IgE)指标的变化,以进一步探讨其治疗作用机制。方法应用氨水和松节油直接作用于大耳白家兔咽部黏膜制备慢性咽炎病理模型,以射干提取物进行治疗,观察药物对模型动物血清IL-4和Ig E表达的影响。结果模型组动物血清中的IL-4和Ig E含量显著高于空白组(P<0.05),经射干提取物治疗后血清中IL-4和Ig E水平均较模型组降低。结论射干治疗慢性咽炎药理活性作用可能是通过调节细胞因子的表达而实现的。Objective To study the expression of interleukin- 4 and IgE in the pharyngitis rabbit model with the Rhizoma Belamcandae extracts to explore its treatment mechanism. Methods White rabbits were used in this study to prepare the model of chronic pharyngitis,induced by directly applied into the pharyngeal mucosa with ammonia water and turpentine oil at first. Then,these modeling animals were divided into several groups,with the Rhizoma Belamcandae extracts taken to treat this kind of lesion. The changes in the expression of IL- 4 and Ig E of these animal models were determined to evaluate the pharmacological effects of this solution on the lesion. Results It was shown that the level of IL- 4 and Ig E were reduced among the animals in treating group（ P〈0. 05）. Conclusion The therapeutic mechanisms of Rhizoma Belamcandae extracts or the treatment of chronic pharyngitis may be achieved by regulating the expression of cytokines.

关 键 词：射干提取物 慢性咽炎 细胞因子 作用机制 

分 类 号：R285.5[医药卫生—中药学] R282.71[医药卫生—中医学]