中毒性表皮坏死松解型药疹20例疗效分析  

Analysis of the Therapy Effect of 20 Cases of Drug-related Toxic Epidermal Necrolysis

作　　者：王利[1] 张小玲[1] 刘敏龙[1] 赵玉杰[1] 郭蕾[1] 王国恩[1] 

机构地区：[1]西安交通大学第二附属医院重症医学科,陕西西安710004

出　　处：《中国皮肤性病学杂志》2016年第5期473-474,550,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨中毒性表皮坏死松解型药疹的治疗策略及其对预后的影响。方法对本科2012年1月-2015年1月收治的20例中毒性表皮坏死松解型药疹患者的临床资料进行回顾性分析。结果 20例患者中,16例治愈,4例死于重症感染及脏器功能衰竭等。糖皮质激素联合丙种球蛋白治疗组平均退热时间为(3.57±2.01)d,皮疹开始消退时间为(3.15±1.64)d,ICU治疗时间(11.62±8.21)d,转出ICU至普通病房治疗时间为(10.21±6.22)d。糖皮质激素联合血浆置换治疗组依次为(1.50±0.57)d,(2.25±0.50)d,(5.50±0.57)d和(7.00±2.00)d。结论糖皮质激素联合血浆置换治疗病程较糖皮质激素联合丙种球蛋白治疗病程短,ICU治疗所需时间短,可减少患者痛苦。Objective To investigate the treatment strategies and prognosis of toxic epidermal necrolysis. Methods Clinical data of 20 patients with toxic epidermal necrolysis from January 2012 to January 2015 were retrospectively analyzed. Results Sixteen patients were discharged. Four cases dead caused by severe infections and organ failure. For glucocorticoid and gamma globulin treated patients, the fever-declining time was （3.57 ± 2. 01 ） d; astringing time of eruption was （3.15 ± 1.64） d; ICU length of stay was （ 11.62 ± 8. 21 ） d; after ICU rehabilitation time was （ 10. 21 ± 6.22） d. They were （ 1.50 ±0. 57） d, （2. 25 ±0. 50） d, （5.50 ±0. 57） d and （7. 00 ± 2. 00） d respectively in patients treated with glucocorticoid and plasma exchange. Conclusion Compared with glucocorticoid and gamma globulin group, the course and ICU staying time were shorter in glucocorticoid and plasma exchange group. It can reduce patients＇ suffering.

关 键 词：中毒性表皮坏死松解型药疹 治疗 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]