间充质干细胞在肿瘤靶向递药系统中的应用  

Engineered mesenchymal stem cells as targeting therapeutic carriers in cancer therapy

作　　者：赵月葵 唐珊珊[2] 张艳峰[2] 宗莉[1] 金亮[2] 

机构地区：[1]中国药科大学药剂学教研室,南京210009 [2]中国药科大学生命科学与技术学院分子生物学教研室,南京210009

出　　处：《中国药科大学学报》2016年第2期134-139,共6页Journal of China Pharmaceutical University

基　　金：国家高技术研究发展计划("八六三"计划)资助项目(No.2015AA020314);国家自然科学基金资助项目(No.81570696;No.31270985);江苏省杰出青年基金资助项目(No.BK20140029)~~

摘　　要：间充质干细胞(mesenchymal stem cells,MSCs)是干细胞家族的重要成员,来源于发育早期的中胚层和外胚层,属于多能干细胞,由于其具有分化潜力大、增殖能力强、免疫原性低、肿瘤部位趋向性、取材方便、易于工业化制备等特征,有可能成为最具临床应用前景的多能干细胞。本文介绍间充质干细胞的基本特性以及其在肿瘤靶向递药系统中的研究进展、临床应用现状,为间充质干细胞在肿瘤靶向递药系统中的进一步研究提供依据。Mesenchymal stem cells（ MSCs） were derived from the early development stage of mesoderm and ectoderm and considered as one of the important members of stem cells family. Besides that,MSCs can be isolated easily and don＇t have a limitation of moral and ethical problems. Moreover,MSCs can be expanded in vitro which make it possible to use in industrial preparation. Moreover,MSCs possess low immunogenicity and has the ability to home to damaged tissues, tumors, and metastases. Therefore, MSCs possess a set of fairly unique properties which make them ideally suited for clinical applications. This review summarizes the main properties of MSCs and its new progress in drug delivery system in the field of cancer therapy as a basis of further utility of engineered MSCs in the design of targeting drug delivery system.

关 键 词：间充质干细胞 靶向递送系统 抗肿瘤 应用 

分 类 号：R943[医药卫生—药剂学]