血管生长素的差异表达对鉴别前列腺癌雄激素依赖性和非依赖性的临床意义的研究  

Research of ANG differentially expression in identification of androgen-dependent and independent prostate cancer

作　　者：田河[1] 南锡浩[1] 于峰[1] 白吉祥[1] 邸彦橙[1] 郭振海[1] 吴影[1] 

机构地区：[1]牡丹江医学院红旗医院泌尿外科,黑龙江牡丹江157011

出　　处：《中国性科学》2016年第4期5-7,共3页Chinese Journal of Human Sexuality

基　　金：2014年黑龙江省教育厅科学技术研究项目(12541844)

摘　　要：目的:研究雄激素依赖性和非依赖性前列腺癌中血管生长素(ANG)的差异性表达的临床意义,以了解雄激素非依赖性前列腺癌的发病机制。方法:研究时间为2013年7月至2015年7月,采用体外培养的方式分别培养雄激素依赖性(LNCa P细胞)和非依赖性(PC-3细胞)前列腺癌细胞株,并与正常健康人群进行对比;分别在细胞和组织水平上对ANG水平和表达情况进行分析归纳。结果:前列腺癌患者ANG阳性表达率显著高于正常健康人群(P<0.05);雄激素依赖性前列腺癌患者各分期中ANG水平明显低于非依赖性患者,P<0.05,统计学具有显著差异意义。结论:ANG在雄激素依赖性前列腺癌向非依赖性前列腺癌转化中具有主导作用,ANG可能成为肿瘤的标记物。Objectives：To study the clinical significance of differential expression of ANG in androgen-dependent and independent prostate cancer in order to understand the pathogenesis of androgen-independent prostate cancer.Methods：From July 2013 to July 2015,by way of in vitro culture,we got androgen-dependent （LNCa P cells） and independent （PC-3 cells） prostate cancer cell lines.The cell sample from healthy people was used as control sample;ANG and expression levels at the cellular and tissue levels were respectively analyzed and summarized.Results：ANG expression in prostate cancer patients were significantly higher than that in normal healthy population （P〈0.05）.In various stages,ANG levels of androgen-dependent prostate cancer were significantly lower than that of non-dependent prostate cancer,with statistically significant difference （P〈0.05）.Conclusion：ANG has a leading role in the conversion to non-independent prostate cancer in androgen dependent prostate cancer and ANG may become tumor marker.

关 键 词：雄激素依赖性前列腺癌 雄激素非依赖性前列腺癌 血管生长素 差异表达 

分 类 号：R737.25[医药卫生—肿瘤]