乳酸杆菌活菌制剂治疗阴道炎效果和安全性分析  

Efficacy and safety analysis of live lactobacillus preparation in patients with vaginitis

作　　者：时建荣 黄庆义[2] 杨瑞[2] 

机构地区：[1]济源市中医院妇产科,河南济源454650 [2]南阳市中心医院妇产科,河南南阳473002

出　　处：《中国性科学》2016年第4期71-74,共4页Chinese Journal of Human Sexuality

摘　　要：目的:探讨乳酸杆菌活菌制剂治疗阴道炎的有效性及安全性。方法:选取344例阴道炎患者随机均分为观察组和对照组,观察组采用甲硝唑联合乳酸杆菌活菌制剂治疗,对照组采用甲硝唑治疗,比较两组临床疗效、不良反应发生及随访期间复发情况。结果:观察组细菌性阴道病、念珠菌性阴道炎及滴虫性阴道炎痊愈率和有效率均明显高于对照组,治疗后3、6、9个月复发率低于对照组,差异具有统计学意义(P<0.05);对照组不良反应发生率为4.7%(4/86),观察组仅出现3例轻度不良反应,发生率为3.5%,且治疗前后血尿常规及肝肾功能检查指标均无显著性变化(P>0.05),两组不良反应发生率差异无统计学意义(P>0.05)。结论:乳酸杆菌活菌制剂治疗阴道炎患者安全有效,可在临床上推广。Objectives：To explore the efficacy and safety of live lactobacillus preparation in patients with vaginitis.Methods：172 patients with vaginitis were randomly divided into observation group and control group.Observation group received the treatment of metronidazole combined with live lactobacillus preparation and control group was treated with metronidazole.The clinical efficacy,adverse reactions and recurrence of two groups were compared.Results：The recovery rate and efficiency of bacterial vaginitis,candida vaginitis and trichomonas vaginitis of observation group were significantly higher than these in control group.The recurrence rate of the 3,6 and 9months after treatment in observation group were lower than these in control group,with statistically significant difference （P〈0.05）.The incidence of adverse reactions in the control group was 4.7% （4 /86）.There were only3 cases of mild adverse reactions in the observation group,an incidence rate of 3.5%.There were no significant changes in the hematuria routine and liver and kidney function test before and after the treatment （P〉0.05）,without significant difference in the incidence of adverse reactions between two groups （P〉0.05）.Conclusion：The treatment of live lactobacillus preparation in patients with vaginitis is safe and effective,which can be applied in clinical practice.

关 键 词：乳酸杆菌活菌制剂 阴道炎 有效性 安全性 

分 类 号：R711.31[医药卫生—妇产科学]