低分子肝素钙联合黄芪注射液治疗糖尿病肾病的疗效观察  

Clinical observation of low molecular weight heparin combined with astragalus injection in the treatment of diabetic nephropathy

作　　者：李政[1] 孟华[1] 陈梅[1] 张倩[1] 

机构地区：[1]普兰店市中心医院肾内科,辽宁省普兰店116200

出　　处：《中国基层医药》2016年第8期1165-1167,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：观察低分子肝素钙联合黄芪注射液治疗糖尿病肾病的效果。方法将2013年1月至2014年12月住院治疗的78例糖尿病肾病Ⅲ期的患者纳入观察对象，采用数字表法随机分为两组：对照组41例，采用一般疗法，即应用低蛋白饮食、复方α酮酸、胰岛素、厄贝沙坦、辛伐他汀；治疗组37例，采用在一般疗法基础上加用低分子肝素钙和黄芪注射液。观察两组患者治疗后的尿微量白蛋白、24 h尿蛋白定量的变化情况。结果治疗后尿微量白蛋白转阴率治疗组（75．68％）明显高于对照组（29．27％）（χ2＝16．765， P＜0．01），24 h尿蛋白定量治疗组[（176．2±82．3）mg／24 h]明显低于对照组[（223．8±87．8）mg／24 h]（t＝2．471，P＜0．05）。结论低分子肝素钙联合黄芪注射液能消减糖尿病肾病Ⅲ期的蛋白尿，不失为早期糖尿病肾病的有效干预治疗方法。Objective To observe the effect of low molecular weight heparin calcium combined with astraga-lus injection in the treatment of diabetic nephropathy.Methods From January 2013 to December 2014,78 patients with stage III diabetic nephropathy in our hospital were enrolled into the study.They were randomly divided into con-trol group（41 cases） and treatment group（37 cases）.The control group received general therapy,such as low protein diets,compound alpha keto acid,insulin,irbesartan,simvastatin.The treatment group was treated with low molecular weight heparin calcium and astragalus injection on the basis of general therapy.The changes of urinary albumin and 24 hours urinary protein after treatment in the two groups were observed.Results After treatment,the negative rate of urinary micro albumin in the treatment group （ 75.68%） was significantly higher than that of the control group （29.27%）（χ2 =16.765,P〈0.01）.24 hour urinary protein of the treatment group[（176.2 ±82.3）mg/24h]was significantly lower than that of the control group[（223.8 ±87.8）mg/24h]（t=2.471,P〈0.05）.Conclusion Low molecular weight heparin calcium combined with astragalus injection can reduce the proteinuria of diabetic nephropa-thy,it is an effective intervention therapy for early diabetic nephropathy.

关 键 词：糖尿病肾病 低分子肝素钙 黄芪注射液 

分 类 号：R587.2[医药卫生—内分泌]