超声引导下细针抽吸细胞块免疫组化技术对浅表淋巴结转移癌的诊断价值  

Diagnostic value of ultrasound-guided fine needle aspiration cytology combined with cell block immunohistochemistry for superficial lymph node metastatic carcinoma

作　　者：戴维德[1] 吴明晓[1] 王川予[1] 张征[1] 陈岚[2] 马卫华[1] 韩秀婕[1] 郭发金[1] 

机构地区：[1]北京医院超声科,北京100730 [2]北京医院病理科

出　　处：《山西医科大学学报》2016年第4期369-372,共4页Journal of Shanxi Medical University

基　　金：国家科技支撑计划基金资助项目(2014BAI08B03);北京医院临床新技术准入项目(20150001)

摘　　要：目的评价超声引导下细针抽吸细胞块免疫组化技术对于浅表淋巴结转移癌的诊断价值。方法对70例浅表淋巴结肿大患者进行超声引导下淋巴结细针穿刺抽吸,所获得标本送细胞学检查和细胞块免疫组化检测。将穿刺病理结果与术后病理结果或随访结果进行回顾性分析及对比。结果本组病例穿刺取材成功率为97.1%(68/70)。68例患者中,66例细胞学检查与细胞块免疫组化联合诊断结果与随访结果相符,临床诊断符合率为97.1%。穿刺细胞块免疫组化结果:淋巴结转移癌51例,非淋巴结转移癌17例。术后病理或临床随访结果:淋巴结转移癌53例,非淋巴结转移癌15例。该技术对浅表淋巴结转移癌的诊断敏感度为96.2%(51/53),特异度为88.2%(15/17)。结论超声引导细针抽吸细胞块免疫组化检测技术对浅表淋巴结转移癌的诊断具有简便实用、安全可靠、准确率高的特点,具有较高的临床应用价值和推广前景。Objective To evaluate the clinical value of ultrasound-guided fine needle aspiration cytology combined with cell block immunohistochemistry in diagnosing superficial lymph node metastatic carcinoma. Methods Superficial enlarged lymph node of 70 patients were punctured and aspirated using fine needle under ultrasound guidance. The samples were obtained for cytology and cell block immunohistochemistry. The conclusions and the follow-up results were retrospectively analyzed and compared. Results The puncture successful rate was 97. 1%（ 68 /70）. Among 68 patients,the results of the cytology combined with cell block immunohistochemistry of66 cases were consistent with follow-up results,and the coincidence rate of clinical diagnosis was 97. 1%. The diagnosis results of cytology combined with cell block immunohistochemistry showed 51 cases of lymph node metastatic carcinoma and 17 cases of lymph node non-metastatic carcinoma. The pathology results after operation or follow-up results showed 53 cases of lymph node metastatic carcinoma and 15 cases of lymph node non-metastatic carcinoma. The sensitivity and specificity of cytology combined with cell block immunohistochemistry was 96. 2%（ 51 /53） and 88. 2%（ 15 /17）,respectively. Conclusion Ultrasound-guided fine needle aspiration cytology combined with cell block immunohistochemistry is simple,practical,safe and reliable in diagnosis of superficial lymph node metastatic carcinoma and has higher clinical application value and promotion prospects.

关 键 词：超声引导 淋巴结转移癌 细胞块 免疫组化 

分 类 号：R816.3[医药卫生—放射医学]