Senegenin inhibits neuronal apoptosis after spinal cord contusion injury  

作　　者：Shu-quan Zhang Min-fei Wu Rui Gu Jia-bei Liu Ye Li Qing-san Zhu Jin-lan Jiang 

机构地区：[1]Department of Orthopedics,Nankai Hospital [2]Department of Orthopedics,the Second Hospital of Jilin University [3]Department of Orthopedics,China-Japan Union Hospital,Jilin University [4]Scientific Research Center,China-Japan Union Hospital,Jilin University

出　　处：《Neural Regeneration Research》2016年第4期657-663,共7页中国神经再生研究（英文版）

基　　金：supported by a grant from the Science and Technology Development Plan of Jilin Province of China,No.2011084

摘　　要：Senegenin has been shown to inhibit neuronal apoptosis,thereby exerting a neuroprotective effect.In the present study,we established a rat model of spinal cord contusion injury using the modified Allen＇s method.Three hours after injury,senegenin（30 mg/g） was injected into the tail vein for 3 consecutive days.Senegenin reduced the size of syringomyelic cavities,and it substantially reduced the number of apoptotic cells in the spinal cord.At the site of injury,Bax and Caspase-3 m RNA and protein levels were decreased by senegenin,while Bcl-2 m RNA and protein levels were increased.Nerve fiber density was increased in the spinal cord proximal to the brain,and hindlimb motor function and electrophysiological properties of rat hindlimb were improved.Taken together,our results suggest that senegenin exerts a neuroprotective effect by suppressing neuronal apoptosis at the site of spinal cord injury.Senegenin has been shown to inhibit neuronal apoptosis,thereby exerting a neuroprotective effect.In the present study,we established a rat model of spinal cord contusion injury using the modified Allen＇s method.Three hours after injury,senegenin（30 mg/g） was injected into the tail vein for 3 consecutive days.Senegenin reduced the size of syringomyelic cavities,and it substantially reduced the number of apoptotic cells in the spinal cord.At the site of injury,Bax and Caspase-3 m RNA and protein levels were decreased by senegenin,while Bcl-2 m RNA and protein levels were increased.Nerve fiber density was increased in the spinal cord proximal to the brain,and hindlimb motor function and electrophysiological properties of rat hindlimb were improved.Taken together,our results suggest that senegenin exerts a neuroprotective effect by suppressing neuronal apoptosis at the site of spinal cord injury.

关 键 词：nerve regeneration spinal cord contusion senegenin thinleaf milkwort root motor function apoptosis electrophysiology neural regeneration 

分 类 号：R285.5[医药卫生—中药学]