深度水解蛋白奶粉喂养极/超低出生体重儿的临床研究  

A study on the effects of extensively hydrolyzed formula for very / extremely low birth weight infants

作　　者：罗智花[1] 王杨[1] 王琍琍[1] 

机构地区：[1]安徽医科大学第一附属医院新生儿科,合肥230022

出　　处：《中国新生儿科杂志》2016年第2期110-114,共5页Chinese Journal of Neonatology

摘　　要：目的探讨早期喂养深度水解乳清蛋白奶粉对极/超低出生体重儿近期的影响。方法选取2013年6月至2015年10月本院新生儿科收治的入院日龄<12 h的极/超低出生体重儿,随机分为深度水解蛋白奶粉喂养组(观察组)与早产儿配方奶喂养组(对照组)进行前瞻性研究,排除住院时间<28天者,采用完全随机设计两组独立样本t检验和四格表卡方检验,比较两组患儿胎便排尽时间、恢复出生体重时间、达全肠道喂养时间、平均住院日、喂养不耐受发生率、出生28天时生长发育指标及生化指标。结果最终纳入分析78例,观察组35例,对照组43例。观察组喂养不耐受发生率低于对照组(25.7%比72.0%),胎便排尽时间[(4.9±0.8)天比(8.8±1.6)天]、达全肠道喂养时间[(13.4±2.0)天比(18.9±2.6)天]及平均住院时间[(33.7±5.1)天比(41.8±6.8)天]短于对照组,出生28天时身长[(43.8±1.2)cm比(42.6±2.0)cm]、血清ALB[(32.5±3.0)g/L比(30.0±4.5)g/L]及Hb[(112.4±11.4)g/L比(106.3±13.0)g/L]高于对照组,差异有统计学意义(P<0.05);两组恢复出生体重时间[(10.9±2.2)天比(10.1±1.7)天]、出生28天时头围[(30.3±1.0)cm比(29.7±1.6)cm]及体重[(1 759±107)g比(1 627±435)g]、出院时宫外发育迟缓发生率(40.0%比44.1%)差异无统计学意义(P>0.05)。结论深度水解蛋白奶粉喂养可降低极/超低出生体重儿喂养不耐受发生率,促进胎便排出,缩短达到全肠道喂养的时间及住院时间,但不能促进出生28天时头围和体重增长及降低出院时宫外发育迟缓发生率。Objective To study the effects of extensively hydrolyzed formula for very /extremely low birth weight（ VLBW / ELBW） infants. Methods From Jun. 2013 to Oct. 2015,78 VLBW / ELBW infants admitted to our hospital within 12 hours of birth were randomly assigned into two groups：hydrolyzed protein formula feeding group（ hydrolyzed formula group） and preterm formula feeding group（ control group）. Infants with hospital stay 28 days were excluded. Prospective study was conducted between two groups comparing the duration of meconium discharge,the time required for total enteral feeding average hospital stay,feeding intolerance and physical growth and blood biochemical indices on the 28 th day. Results A total of 78 infants were enrolled,35 in hydrolyzed formula group and 43 in control group. Comparing with control group,feeding intolerance in hydrolyzed formula group was significantly lower（ 25. 7% vs. 72. 0%）. The duration of meconium discharge [（ 4. 9 ± 0. 8） d vs.（ 8. 8 ± 1. 6） d],the time required for total enteral feeding[（ 13. 4 ± 2. 0） d vs.（ 18. 9 ± 2. 6） d] and average hospital stay duration[（ 33. 7 ± 5. 1） d vs.（ 41. 8 ± 6. 8） d] was shorter in hydrolyzed formula group（ P〈0. 05）. The body length on the 28 th day in hydrolyzed formula group was longer than control group[（ 43. 8 ± 1. 2） cm vs.（ 42. 6 ± 2. 0） cm,P〈0. 05]. The concentration of serum albumin[（ 32. 5 ± 3. 0） g /L vs.（ 30. 0 ± 4. 5） g /L] and hemoglobin [（ 112. 4 ± 11. 4） g /L vs.（ 106. 3 ±13. 0） g / L] in hydrolyzed formula group were significantly higher than the control group（ P〈0. 05）. No significant difference was found between the two groups regarding the time required returning to birth weight [（ 10. 9 ± 2. 2） d vs.（ 10. 1 ± 1. 7） d],body weight [（ 1 759 ± 107） g vs.（ 1 627 ± 435） g],head circumference[（ 30. 3 ± 1. 0） cm vs.（ 29. 7 ± 1. 6） cm]on the 28 th day and the incidence of extrauterine growth retardation（ EUGR）（ 40

关 键 词：婴儿 极低出生体重 婴儿 超低出生体重 深度水解蛋白奶粉 早产儿配方奶 

分 类 号：R722.6[医药卫生—儿科]