脂肪与肥胖相关基因对动物脂肪代谢的调节  

Regulation of Fat Mass and Obesity Associated Gene in Animal Fat Metabolism: A Review

作　　者：张莹[1] 吴铁梅[1] 王雪[1] 闫素梅[1] 

机构地区：[1]内蒙古农业大学动物科学学院,呼和浩特010018

出　　处：《动物营养学报》2016年第4期999-1003,共5页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家公益性行业(农业)科研专项(201003061)

摘　　要：脂肪与肥胖相关(fat mass and obesity associated,FTO)基因是一种与普通肥胖相关的等位基因,该基因导致的肥胖是21世纪世界各国面临的最大公共卫生挑战之一。FTO基因与机体的普通肥胖有着密切的关系,而且与脂肪沉积和脂肪代谢相关激素及基因的表达有关。本文综述了FTO基因在脂肪细胞分化和脂肪代谢中的作用,揭示了FTO基因对脂肪沉积的影响,为深入研究动物脂肪代谢的机制提供理论基础。Fat mass and obesity associated（FTO） gene is an allele related common obesity,and causes obesity which is one of the biggest public health challenges around the world in the 21 s century.FTO gene not only has a close relationship with obesity,but also is associated with hormone and gene expression in fat deposition and metabolism.This paper reviewed the FTO gene roles in adipocyte differentiation and fat metabolism,revealed the FTO gene effects on fatty deposits,with the aim of providing theoretical basis for animal fat metabolism mechanism.

关 键 词：FTO基因 脂肪细胞分化 脂肪沉积 

分 类 号：S811[农业科学—畜牧学]