高密度脂蛋白抗动脉粥样硬化的研究进展  

Progress of high density lipoprotein in resisting atherosclerosis

作　　者：朱满[1] 景伟[1] 涂建成[1] 

机构地区：[1]武汉大学中南医院检验系检验科基因诊断中心,430071

出　　处：《中华检验医学杂志》2016年第4期315-318,共4页Chinese Journal of Laboratory Medicine

基　　金：国家重点基础研究发展规划“973计划”项目（2012CB720600）子课题（2012CB720605）

摘　　要：冠状动脉粥样硬化性心脏病是导致全球非感染性疾病死亡的首要原因。高密度脂蛋白（HDL）在抗动脉粥样硬化发生、发展中扮演着重要作用。近年发现，HDL可以携带微小RNA，并通过转运微小RNA实现抗内皮细胞炎症功能。不同HDL亚型在抗动脉粥样硬化中的具体功能开始逐渐被认识。逆向转运胆固醇、抗氧化、抗炎症及内皮细胞保护等一系列传统HDL抗动脉粥样硬化功能也都有了新的研究进展，为HDL的临床应用提供新的依据。Coronary atherosclerotic heart disease is the leading cause of death in the world of non- infectious diseases. High density lipoprotein （HDL） plays an important role in the progression of anti- atherosclerosis. Recent studies have found that HDL can carry microRNA, and the anti-inflammation function of endothelial cell is achieved by the transport of microRNA. The specific functions of different HDL subtypes in the anti-atherosclerosis have been gradually recognized. At the same time, a series of traditional HDL anti-atherosclerotic functions also have been newly discovered, such as reverse cholesterol transport, antioxidant, anti-inflammatory and the protection of vascular endothelium. All of these advances provide a new basis for the clinical application of HDL.

关 键 词：冠心病 脂蛋白类 HDL 动脉粥样硬化 微RNAS 

分 类 号：R543.5[医药卫生—心血管疾病]