老年男性LOH症状与血清T和FT水平相关性分析——来自上海闵行社区的调查  

Correlation analysis between symptoms of late-onset hypogonadism and serum testosterone level in Minhang district of Shanghai

作　　者：贺兴云 屠民琦[2] 王伟 王曦龙[2] 施国伟[2] 何家扬[2] 周任远[2] 

机构地区：[1]上海市静安区中心医院泌尿外科,上海200040 [2]复旦大学附属上海市第五人民医院泌尿外科

出　　处：《临床泌尿外科杂志》2016年第4期367-370,共4页Journal of Clinical Urology

基　　金：上海市闵行区自然科学研究课题(编号2013MHZ018)

摘　　要：目的：了解上海闵行社区老年男性迟发性性腺功能减退（late-onset hypogonadisim,LOH）的患病情况,分析LOH相关症状与血清总睾酮（total testosterone,TT）、游离睾酮（free testosterone,FT）水平之间的关系。方法：2013年3月-2014年4月在上海市闵行区江川街道的三个社区对50岁以上的1 062例老年男性进行LOH症状抽样调查,平均年龄为（71.03±7.59）岁。以老年男性雄激素缺乏量表（androgen deficiency in aging males,ADAM）作为LOH症状指标,以国际勃起功能指数5（international index of erectile function,IIEF5）作为勃起功能障碍（erectile dysfunction,ED）指标。同时测定调查者的TT、FT水平。结果：1 062例老年男性ADAM阳性率为97.65%（1 037/1 062）,IIEF5阳性率为99.44%（1 056/1 062）。其中384例接受了TT、FT检测,平均年龄为（71.12±7.08）岁,平均TT水平为（17.38±3.99）nmol/L,平均FT水平为（236.22±48.08）pmol/L。ADAM阳性且TT〈12nmol/L者占8.1%（31/384）。T〈12nmol/L与T≥12nmol/L者ADAM各项症状差异无统计学意义（P〉0.05）,两者ED的发生率差异也无统计学意义（P〉0.05）;T和FT水平随年龄增长无显著变化（P〉0.05）。结论：上海闵行社区8.1%老年男性符合LOH症状和生化诊断标准;LOH相关症状与血清T水平无明显相关性。Objective：To know the prevalence of late-onset hypogonadism（LOH）in Minhang district of Shanghai and analyse the correlation between symptoms of LOH and serum total testosterone（TT）or free testosterone（FT）levels.Method：During an aging people screening program,we surveyed responses to Androgen Deficiency in Aging Males（ADAM）questionnaire and International Index of Erectile Function（IIEF5）in terms of LOH symptoms and evaluated serum TT and FT levels in healthy community-living volunteers aging over 50 years old in Minhang District of Shanghai from March 2013 to April 2014.Result：There were 1 062 aging males who responded to ADAM and IIEF5,and their positive rates to ADAM and IIEF5 were 97.65%and 99.44%respectively.There were 384 males receiving TT and FT measurement,whose mean age was（71.12±7.08）.Their mean TT level was（17.38±3.99）nmol/L,and mean FT level was（236.22±48.08）pmol/L.The percentage of volunteers who were positive to ADAM and TT level was less than 12nmol/L was 8.1%（31/384）.There was no significant difference in symptoms of LOH and erectile dysfunction（ED）between T12nmol/L group and T≥12nmol/L group（P〈0.05）.There was no significant correlation among serum T,FT levels and volunteers＇ age（P〈0.05）.Conclusion：Among over 50 years of age males,8.1% met the clinical and biochemical diagnostic criteria for LOH.There was no significant correlation between LOH symptoms and serum T levels.

关 键 词：迟发性性腺功能减退症 雄激素缺乏 睾酮 勃起功能障碍 

分 类 号：R698[医药卫生—泌尿科学]