冠心止痛合剂治疗冠心病心绞痛临床疗效观察  

Clinical Effect of Coronary Heart Disease with Angina Pectoris Treated with Guanxin Zhitong Mixture

作　　者：彭立萍[1] 

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医杂志》2016年第4期788-791,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:观察冠心止痛合剂治疗冠心病心绞痛的临床疗效。方法:将70例冠心病心绞痛患者随机分为治疗组与对照组两组,每组各35例。所有患者均接受一般治疗,对照组予舒血宁注射液及硝酸甘油注射液静点,1次/d,同时口服硝酸异山梨酯片,每次10 mg,3次/d,治疗组在上述治疗基础上口服中药冠心止痛合剂,并随证加减,疗程为4周,疗程结束后观察疗效。结果:两组治疗后临床疗效比较,治疗组为91.4%,对照组为74.3%,两组相比,有统计学差异(P<0.05)。在心电图疗效比较中,治疗组有效率为85.7%,对照组有效率为68.6%,两组相比,有统计学差异(P<0.05)。治疗后治疗组发作次数、持续时间及平均住院时间均少于对照组,两组相比,有统计学差异(P<0.05)。两组治疗后CK-MB及c Tn I水平比较中,治疗组明显低于对照组,两组相比,差异有统计学意义(P<0.05)。结论:口服冠心止痛合剂可以明显提高临床疗效及心电图疗效,同时改善心绞痛症状,缩短住院时间,还能有效地降低CK-MB及心肌钙蛋白水平,且无明显不良反应,值得临床推广使用。Objective： To observe the clinical effect of Guanxin Zhitong Mixture in the treatment of coronary heart disease with angina pectoris. Methods： Seventy patients with angina pectoris were randomly divided into treatment group and control group,35 in each group. All patients received general treatment. Patients in control group were treated with Shuxuening Injection and nitroglycerin intravenous injection,once a day,and also oral Isosorbide Dinitrate Tablets,10 mg for each time,three times a day. The treatment group on the basis of the above used oral medicine Guanxin Zhitong Mixture for 4 weeks. At the end of treatment,the curative effect was observed. Results： The clinical efficacy of the treatment group was 74. 3% and that of the control group91. 4%. Compared with the two groups,there were significant differences（ P〈0. 05）. In the comparison of ECG,the effective rate of the treatment group was 85. 7% and the control group＇ s was 68. 6% and the two groups were significantly different（ P〈0.05）. After treatment,the number of attacks,duration and average length of hospital stay were less than those of the control group and the two groups were significantly different（ P〈0. 05）. The levels of c Tn I and CK-MB in the two groups were significantly lower than those in the control group and the difference was statistically significant（ P〈0. 05）. Conclusion： Oral administration of Guanxin Zhitong Mixture can not only significantly improve the clinical curative effect and electrocardiogram efficacy and improve the symptoms of angina and shorten the length of hospital stay,but also can effectively reduce the CK-MB and cardiac troponin levels,and has no obvious side effects,worthy of clinical use.

关 键 词：冠心止痛合剂 冠心病心绞痛 中医中药 疗效观察 

分 类 号：R541.4[医药卫生—心血管疾病]