二氯甲烷毒性及生物监测的研究进展  

Toxicity and bio-monitoring of dichloromethane: a review of recent studies

作　　者：张明[1] 闫欢[1] 刘保峰[1] 

机构地区：[1]天津市疾病预防控制中心职业病预防控制所,天津300011

出　　处：《环境与健康杂志》2015年第12期1108-1112,共5页Journal of Environment and Health

基　　金：2013年卫生部标准制(修)订项目(20130208);天津市应用基础与前沿技术研究计划项目(15JCQNJC45100)

摘　　要：二氯甲烷是一种被广泛使用的有机溶剂,美国毒物和疾病登记署(ATSDR)将二氯甲烷列为可疑人类致癌物,该文就近年来二氯甲烷的体内代谢和吸收、致癌性、神经毒性、心血管毒性、生物暴露标志物及生物监测研究进展进行综述。Dichloromethane is slightly soluble in water, and soluble in ether and ethanol, which widely was used as a solvent.Improper use of dichloromethane can induce poisoning due to its volatility at room temperature. Dichloromethane has recently been classified as a possible human carcinogen by The Agency for Toxic Substances and Disease Registry（ATSDR） and its adverse effects on human health has been more and more focused on. In the present article the recent studies on absorption and metabolism in vivo, carcinogenicity, neurotoxicity, cardiovascular toxicity, biomarkers, toxicity and bio-monitoring of dichloromethane were reviewed.

关 键 词：二氯甲烷 毒性 职业暴露 生物限值 

分 类 号：R994.6[医药卫生—毒理学]