海洋放线菌Streptomyces sp.WQ-2化学成分研究  

Chemical constituents of marine-derived actinomycete Streptomyces sp.WQ-2

作　　者：申丽[1] 李晓雯[1] 魏中琦[1] 朱力[1] 杨长水[1] 宋勇春[2] 

机构地区：[1]扬州大学医学院,江苏扬州225001 [2]南京大学功能生物分子研究所,江苏南京210046

出　　处：《扬州大学学报（农业与生命科学版）》2015年第4期18-21,共4页Journal of Yangzhou University：Agricultural and Life Science Edition

基　　金：国家自然科学基金资助项目(21372191);江苏省自然科学基金青年基金资助项目(BK20130439)

摘　　要：采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱和高效液相色谱等方法对海洋放线菌Streptomyces sp.WQ-2固体发酵产物的化学成分进行分离纯化,并利用质谱、核磁共振谱及文献比对方法鉴定化合物的结构。结果表明:从Streptomyces sp.WQ-2固体发酵产物中分离得到5个化合物,分别被鉴定为D-阿洛醇(1)、胡萝卜苷(2)、5-oxo-pyrrolidine-2-carboxylic acid(3)、麦角甾醇(4)和lumichrome(5)。其中,化合物1、3和5首次从Streptomyces sp.发酵产物中分离获得。Isolation and purification of chemical constituents from solid culture of marine-derived actinomycete Streptomyces sp.WQ-2was performed through silica gel column chromatography,gel filtration with Sephadex LH-20 and HPLC method etc.Structures of obtained compounds were elucidated by MS and NMR data and compared with literatures.Five compounds were isolated from the solid culture of Streptomyces sp.WQ-2,which were identified as D-allitol（1）,daucosterol（2）,5-oxo-pyrrolidine-2-carboxylic acid（3）,ergosterol（4）and lumichrome（5）,respectively.Compounds 1,3and 5were first obtained from culture of Streptomyces sp.

关 键 词：放线菌 链霉菌 次生代谢产物 结构鉴定 

分 类 号：R284.2[医药卫生—中药学]