换血方法治疗新生儿溶血病的临床疗效  

Clinical effect by exchange transfusion in the treatment of hemolytic disease of the newborn

作　　者：赵鲁强[1] 

机构地区：[1]贵州医科大学附属医院输血科,550001

出　　处：《中国实用医药》2016年第8期29-30,共2页China Practical Medicine

摘　　要：目的探讨换血方法治疗新生儿溶血病(HDN)的临床效果。方法 120例HDN患儿进行换血治疗,分别检测患儿在换血前后的血清总胆红素、直接胆红素、间接胆红素及Na+、Cl-、Ca2+、K+的水平变化。结果 120例患儿换血后血清总胆红素、直接胆红素和间接胆红素水平与换血前比较均明显降低,差异均有统计学意义(P<0.05)。120例患儿与换血前比较,换血后Na+、Cl-、Ca2+水平均显著升高,K+显著下降,差异均有统计学意义(P<0.05)。结论换血方法可以降低HDN患儿胆红素水平,纠正电解质紊乱,临床值得推广应用。Objective To investigate clinical effect by exchange transfusion in the treatment of hemolytic disease of the newborn（HDN）. Methods A total of 120 infants with HDN received exchange transfusion. Their changes of serum total bilirubin, direct bilirubin, indirect bilirubin, level changes of Na＋, Cl-, Ca2＋, and K＋ were all detected before and after exchange transfusion. Results The differences of serum total bilirubin, direct bilirubin, and indirect bilirubin, which were abviously decreased, before and after exchange transfusion had statistical significance in 120 cases（P〈0.05）. Comparing with those before exchange transfusion, all the 120 cases had much higher Na＋, Cl-, Ca2＋ levels after exchange transfusion, and K＋ level was obviously reduced after exchange transfusion, and the differences had statistical significance（P〈0.05）. Conclusion Exchange transfusion can decrease bilirubin level and correct electrolyte disturbance in HDN infants. This method is worth clinical promotion and application.

关 键 词：新生儿溶血病 换血 临床疗效 

分 类 号：R722.18[医药卫生—儿科]