Efficacy and safety of a novel multi-electrode radiofrequency ablation catheter for renal sympathetic denervation in pigs  

作　　者：Qian GAN Xin-Kai QU Kai-Zheng GONG Shao-Feng GUAN Wen-Zheng HAN Jin-Jie DAI Ruo-Gu LI Min ZHANG Hua LIU Ying-Jia XU You-Jun ZHANG Wei-Yi FANG 

机构地区：[1]Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China [2]Department of Cardiology, the Second Clinic Medical College, Yangzhou University, Yangzhou, China

出　　处：《Journal of Geriatric Cardiology》2015年第6期618-625,共8页老年心脏病学杂志（英文版）

摘　　要：Objective To investigate the safety and efficacy of a self-developed novel multi-electrode radiofrequency ablation catheter （Spark） for catheter-based renal denervation （RDN）. Methods A total of 14 experimental miniature pigs were randomly divided into four groups （55°＆ 5-watt, 55°＆ 8-watt, 65°＆ 5-watt, and 65° ＆ 8-watt groups）. Spark was used for left and right renal artery radiofrequency ablation. Blood samples collected from renal arteries and veins as well as renal arteriography were performed on all animals before, immediately after, and three months after procedure to evaluate the effects of Spark on the levels of plasma renin, aldosterone, angiotensin I, and angiotensin II as well as the pathological changes of renal arteries. Results One pig died of an anesthetic accident, 13 pigs successfully underwent the bilateral renal artery ablation. Compared with basic measurements, pigs in all the four groups had significantly decreased mean arterial pres- sure after procedure. Histopathological analysis showed that this procedure could result in intimal hyperplasia, significant peripheral sympa- thetic nerve damage in the renal arteries such as inflammatory cell infiltration and fibrosis in perineurium, uneven distribution of nerve fibers, tissue necrosis, severe vacuolization, fTagmented and unclear nucleoli myelin degeneration, sparse axons, and interruption of continuity. In addition, the renal artery radiofrequency ablation could significantly reduce the levels of plasma renin, aldosterone, angiotensin I, and angio- tensin II in pigs. Conclusions The results suggest that this type of multi-electrode catheter-based radiofrequency ablation could effectively remove peripheral renal sympathetic nerves and reduce the activity of systemic renin-angiotensin system in pigs, thus facilitating the control of systemic blood pressure in pigs.

关 键 词：Multi-electrode catheter Radiofrequency ablation Renal artery 

分 类 号：Q95-33[生物学—动物学] Q421