2011-2013年某院抗菌药物的使用及细菌耐药性分析  

Analysis of antibacterial usage and bacterial resistance in a hospital between 2011 and 2013

作　　者：郑继标 陈丽莲[1] 陈娟[1] 吴雄辉[1] 李琼[1] 黄云平[1] 

机构地区：[1]广东省湛江中心人民医院,广东湛江524037

出　　处：《广东医学院学报》2015年第5期580-583,共4页Journal of Guangdong Medical College

摘　　要：目的了解某院住院患者抗菌药物使用量及细菌耐药情况。方法总结某院2011-2013年住院患者12类抗菌药物的使用情况,分析用药频度(DDDs)和主要病原菌药敏试验结果。结果 3年间抗菌药物的总用药频度增长111.17%,头孢菌素类DDDs居第一位。常见革兰阴性菌对阿莫西林/克拉维酸、青霉素G、头孢唑林、头孢呋辛、头孢噻肟耐药率均大于40%,其中铜绿假单胞菌和鲍曼不动杆菌耐药率大于70%。结论抗菌药物的使用量影响细菌耐药水平的动态变化,抗菌药物的合理应用、干预和监管可减缓细菌耐药性发生。Objective To study the antibacterial usage and bacterial resistance in a hospital. Methods The data of 12 antibiotics in hospitalized patients were summarized in a hospital from 2011 to 2013. The defined daily doses（DDDs） and susceptibility test results of main pathogens were analyzed. Results The overall frequency of antibiotic use was increased by 111.17% during 3 years. The DDDs of cephalosporins were ranked the first. The resistance rates of amoxicillin/clavulanate, penicillin G, cefazolin, cefuroxime and cefotaxime against common Gram-negative bacteria were more than 40%, of which they were over 70% against Pseudomonas aeruginosa and Acinetobacter baumanmii. Conclusion The doses of antibacterial agents can affect the dynamic changes of drug resistance. The rational usage, interference and supervision of antibacterial agents may mitigate the development of drug resistance.

关 键 词：抗菌药物 耐药 药敏试验 

分 类 号：R969.3[医药卫生—药理学]