尿激酶型纤溶酶原激活物及纤溶酶原激活物抑制物1与女性免疫不孕症发病机制的相关研究  

Study on Relevance Between the uPA, tPA and PAI-1 of the Endometrium and the Mechanism of Immune Infertility

作　　者：杨红[1] 鱼瑛[1] 顾惠芳[1] 陆维娜[1] 杨嫣红[1] 俞莉雯 奚秋萍[1] 

机构地区：[1]江苏省常熟市第一人民医院妇产科,江苏常熟215500

出　　处：《中国血液流变学杂志》2015年第3期338-341,共4页Chinese Journal of Hemorheology

摘　　要：目的：探讨尿激酶型纤溶酶原激活物（uPA）、组织型纤溶酶原激活物（tPA）及纤溶酶原激活物抑制物1（PAI-1）表达与免疫不孕症机制的相关性。方法采用免疫组织化学及RT-PCR方法检测30例免疫不孕症患者（不孕组）及30名正常生育者（正常组）着床窗期子宫内膜uPA、tPA及PAI-1表达，并采用t检验进行统计。结果不孕组子宫内膜uPA （1.33±2.18）明显低于正常组（2.83±1.97），差异有统计学意义（P＜0.05）；不孕组子宫内膜PAI-1（2.68±1.72）明显高于正常组（1.24±1.90），差异有统计学意义（P＜0.01）；不孕组子宫内膜tPA与正常组差异无统计学意义（1.47±1.64、1.60±2.08，P＞0.05）。结论免疫不孕症患者着床窗期子宫内膜uPA/PAI-1与正常人具有明显差异，与免疫不孕症的发病机制具有密切关联。Objective To explore the relevance between the uPA, tPA and PAI-1 of the endometrium and the mechanism of immune infertility.Methods Using immunohistochemistry, Western blot and RT-PCR methods test the expression of uPA, tPA and PAI-1 in the implantation window of endometrium fr om 30 cases immune infertility patients and 30 fertility （control group）, and data using thet test.Results uPA of endometrium from immune infertility group （1.33±2.18） is signifi cantly lower than the control group （2.83±1.97）, the difference is statistically significant （P〈0.05）; PAI-1 of endometrium from immune infertility group （2.68±1.72） is signifi cantly higher than control group （1.24±1.90）, the difference is statistically signifi cant （P〈0.01）; tPA of endometrium from immune infertility group and the control group has no significant difference （1.47±1.64, 1.64±2.08,P〉0.05）.Conclusion uPA/PAI-1 of endometrium from the immune infertility patients and fertility has obvious difference, and it has a close correlation with the pathogenesis of immune infert ility.

关 键 词：免疫性不孕 着床窗子宫内膜 尿激酶型纤溶酶原激活物 组织型纤溶酶原激活物 纤溶酶原激活物抑制物1 

分 类 号：R711.6[医药卫生—妇产科学]