运脾消食颗粒对厌食症大鼠模型血清八肽胆囊收缩素、锌含量影响的研究  

Research on effect of Yunpi Xiaoshi granule on serum contents of CCK-8 and zinc in anorexia rat models

作　　者：杜晨光[1] 丁培杰[1] 曹颖[1] 徐丁洁[1] 郑彩慧[1] 白素芬[1] 柳月娟[1] 董玉山[1] 

机构地区：[1]河北联合大学中医学院,河北唐山063000

出　　处：《山西中医学院学报》2015年第6期1-3,共3页Journal of Shanxi College of Traditional Chinese Medicine

基　　金：唐山市科技局指导项目(13130216b);河北省中医药管理局指令项目(2014054)

摘　　要：目的:探讨运脾消食颗粒对厌食症大鼠模型血清八肽胆囊收缩素(CCK-8)、锌(Zn)含量的影响。方法:采用病因模拟法建立厌食症动物模型,分别对模型大鼠摄食量、体质量以及血清CCK-8、Zn含量进行检测。结果:运脾消食颗粒可以明显增强厌食症大鼠的食欲,增加体质量,降低血清CCK-8含量,提高血清Zn含量,与模型对照组比较,差异均有统计学意义(P<0.05,P<0.01)。结论:运脾消食颗粒对厌食症大鼠模型具有明显治疗作用,其发挥临床疗效的作用机制可能是通过调节血清CCK-8、Zn含量实现的。Objective：To study the effect of Yunpi Xiaoshi granule on serum content of CCK-8 and zinc in anorexia rat models. Methods：The etiology simulation method was adopted to establish anorexia rat models. Then food intake,weight of rats and serum contents of CCK-8 and zinc were detected. Results：Compared with model control group,the appetite,weight and serum content of zinc of rats were increased,serum CCK-8 level was decreased in Yunpi Xiaoshi granul groups（P〈0.05,P〈0.01）. Conclusion：Yunpi Xiaoshi granule has obvious therapeutic effect on anorexia models. Its mechanism maybe through regulating serum CCK-8 and zinc content.

关 键 词：运脾消食颗粒 厌食症模型 八肽胆囊收缩素 锌 

分 类 号：R285[医药卫生—中药学]