HI-13串列加速器生物样品辐照用新终端~7Li离子束流监测诊断研究  

Diagnostics and Measurements of ~7Li Ion Beam on the New Terminal at HI-13 Tandem Accelerator for Biological Samples Irradiation

作　　者：隋丽[1] 张小玲[1] 孔福全[1] 沈东军[1] 刘建成[1] 

机构地区：[1]中国原子能科学研究院核物理研究所,北京102413

出　　处：《原子核物理评论》2015年第4期467-472,共6页Nuclear Physics Review

基　　金：中国原子能科学研究院院长基金(11YZ-201101)~~

摘　　要：7Li离子属于高LET辐射,是辐射生物学基础研究中常用的重离子射线之一,它是硼中子俘获治疗癌症中起关键作用的离子,在辐射诱变育种等领域也有较好的应用前景。实验在北京HI-13串列加速器R20支线生物用新终端上进行,对43 MeV^7Li离子束照射野大小、均匀性和监测注量的准确性进行测量和评估,结果表明:5.0 cm×5.0 cm范围内照射野均匀性达到91.2%;4.2×10~4~1.5×10~5particles/cm^2/s注量率范围内,两种不同探测器测得的注量率变化呈线性关系,闪烁体探测器监测的注量与CR39探测器测得的绝对注量的误差小于10%。这些束流特性能够基本满足辐射生物学实验要求,有利于进一步开展与硼中子俘获治疗癌症或辐射诱变育种中~7Li离子的辐射生物学相关研究。-7Li ion with high linear energy transfer（LET） radiation has been used in radiobiological research,which is key particle in Boron Neutron Capture Therapy（BNCT） and is applied in radiation mutagenic breeding.In present study, the new terminal had been established for radiobiological application, located at the end of R20 branch beam line of HI-13 tandem accelerator. The beam qualities of -7Li ions of 43 Me V generated by HI-13 tandem accelerator, including spot size, uniformity and particle fluence accuracy, were measured using different detection methods. The results showed that beam uniformity was 91.2% at 5.0 cm×5.0 cm area, the flux measured using different detectors had a good linear relationship as particle flux ranged from 4.2 × 10^4particles/cm^2/s to 1.5×10^5particles/cm^2/s and particle fluence accuracy was better than 90%. All the results showed that the beam qualities of -7Li ions basically met the requirements for radiation biological experiment. It provided important method to study biological effects in fundamental research and radiation therapy or radiation mutagenic breeding application associated with -7Li ions.

关 键 词：7Li离子 高LET辐射 束流均匀性 注量准确性 

分 类 号：TL52[核科学技术—核技术及应用]