慢性肺心病急性发作期与缓解期血清超敏C反应蛋白、心肌酶水平的变化  

The levels of high-sensitivity C reactive protein and serum myocardial enzyme during acute exacerbation and remission in chronic pulmonary heart disease

作　　者：舒思亮 

机构地区：[1]杭州市拱墅区大关上塘街道社区卫生服务中心,浙江杭州310014

出　　处：《健康研究》2016年第2期162-164,共3页Health Research

摘　　要：目的探讨慢性肺心病急性发作期及治疗缓解期的血清超敏C反应蛋白(hs-CRP)、心肌酶及血清脑钠肽(BNP)的变化情况。方法选取120例慢性肺心病患者,其中急性发作期60例,缓解期60例,检测其血清hs-CRP及心肌酶,并以60例健康体检者作为对照。结果慢性肺心病患者的hs-CRP、BNP、CK-MB水平显著高于健康对照组,而急性发作期则明显高于缓解期(P<0.01)。经治疗,急性发作期患者的hs-CRP、BNP、CK-MB以及血气分析水平均明显改善(P<0.01)。结论慢性肺心病患者血清hs-CRP、心肌酶水平显著升高,尤其是急性发作期,故可作为预测慢性肺心病产生、进展及疗效判断的重要指标。Objective To understand the changes of serum high-sensitivity C-reactive protein（ hs-CRP）,cardiac enzymes and serum B-type natriuretic peptide during the period of acute exacerbation and therapy remission in chronic pulmonary heart disease. Method 120 patients with chronic pulmonary heart disease were chosen as the subjects of study,which included 60 cases of acute exacerbation and 60 cases of remission. The serum hs-CRP and cardiac enzymes were detected.60 cases of healthy subjects were chosen as the control group. Findings In patients with chronic pulmonary heart disease,the hs CRP and BNP,CK levels was significantly higher than those of the control group. The rate of acute exacerbation was significantly higher than the rate of remission（ P〈0. 01）. After the treatment,significant improvement was identified in patients with hs-CRP,BNP,CK-MB and in blood gas analysis in patients with acute attack（ P〈0. 01）. Conclusion Serum hs-CRP,cardiac enzyme levels of patients with chronic pulmonary heart disease significantly increased,especially during acute exacerbation. It can serve as an indicator of chronic pulmonary heart disease.

关 键 词：慢性肺心病 急性发作期 缓解期 hs-CRP 心肌酶 

分 类 号：R541.5[医药卫生—心血管疾病]