生长分化因子-15的检测在2型糖尿病肾病的临床意义  

Clinical significance of growth differentiation factor-15 in type 2 diabetic nephropathy

作　　者：郝猛[1] 施珍[1] 刘晓峰[1] 

机构地区：[1]九江市第一人民医院/南昌大学附属九江医院检验科,江西九江332000

出　　处：《实验与检验医学》2016年第2期170-173,共4页Experimental and Laboratory Medicine

摘　　要：目的探讨生长分化因子-15(GDF-15)对2型糖尿病肾病中的临床诊断意义。方法测定25名健康对照者和85名2型糖尿病患者的血清生长分化因子-15(GDF-15),分析其与尿微量白蛋白(m Alb)、尿素氮(BUN)、血肌酐(SCr)和血尿酸(UA)的相关性。结果大量白蛋白尿组、微量白蛋白尿组GDF-15水平均高于正常蛋白尿组,均具有统计学意义(P<0.05);相关性分析显示,GDF-15水平与BUN、SCr、m Alb水平呈正相关,与e GFR呈负相关,与UA无相关性;另以e GFR<90ml/min/1.73m2作为肾功能受损的诊断标准绘制受试者工作特征曲线(ROC),GDF-15和m Alb的曲线面积分别为0.795和0.726;根据cutoff值计算GDF-15和m Alb诊断肾功能受损的敏感度分别为:83.6%、81.7%,特异度分别为:64.5%、62.8%。结论血清生长分化因子-15(GDF-15)的检测在2型糖尿病肾病的早期诊断具有良好的临床价值。Objective To investigate the clinical diagnostic value of growth differentiation factor-15（GDF-15） in type 2 diabetic nephropathy. Methods Serum GDF-15 was measured in 25 healthy controls and 85 patients with type 2 diabetes mellitus,and urinary albumin（m Alb）,urea nitrogen（BUN）,serum creatinine（SCr） and serum uric acid（UA） were analyzed. Results In macroalbuminuria group and microalbuminuria group,GDF-15 levels were higher than that in normal albuminuria group,with statistically significance（P〈0.05）. Correlation analysis showed that GDF-15 level was positively correlated with the level of BUN,SCr,m Alb,and negatively correlated with e GFR,without correlation with UA. In addition,we chose the e GFR90ml/min/1.73m^2 as renal damage diagnosis standard,the receiver-operating characteristic curve（ROC） was drawn. The area under curve of GDF-15 and m Alb were 0.795 and 0.726 respectively. For GDF-15 and m Alb,the sensitivity of the diagnosis of renal damage were 83.6% and81.7% respectively,and the specificity were 64.5% and 62.8% respectively. Conclusion The detection of serum growth differentiation factor-15（GDF-15） has good clinical value in the early diagnosis of type 2 diabetic nephropathy.

关 键 词：生长分化因子-15 尿微量白蛋白 2型糖尿病 肾病 

分 类 号：R587.1[医药卫生—内分泌] R446.62[医药卫生—内科学]